Background
Methods
Study design and population
Vest technology and development
Electrodes
Textile garment
Vest design
Leads and amplifier
ECG signal collection
CMR scan
Cardiac segmentation
Landmark localisation (manual and automated)
ECGI signal post processing
Repeatability studies
Statistical methods
Results
Baseline characteristics
Group | Younger age participants (HV) n = 27 | Older age participants (MyoFit46) n = 50 | p value* |
---|---|---|---|
Demographics | |||
Age, years | 38.9 ± 8.5 | 77.0 ± 0.1 | < 0.001 |
Male, n | 9 [35] | 26 [51] | 0.23 |
BSA, m2 | 1.79 ± 0.25 | 1.82 ± 0.17 | 0.57 |
Heart rate, bpm | 68 ± 11 | 63 ± 9.7 | 0.08 |
Past medical history | |||
T2DM | 0 (0) | 2 (4) | NA |
HTN | 0 (0) | 15 (30) | NA |
Chol | 0 (0) | 18 (36) | NA |
MI | 0 (0) | 1 (2) | NA |
IHD | 0 (0) | 3 (6) | NA |
AF | 0 (0) | 0 (0) | NA |
AB | 0 (0) | 2 (4) | NA |
ACEi | 0 (0) | 11 (22) | NA |
BB | 0 (0) | 4 (4) | NA |
CCB | 0 (0) | 6 (6) | NA |
CMR parameters | |||
LAVi,ml | 21 ± 3.9 | 22 ± 6.8 | 0.28 |
LVEDVi, ml | 81 (12) | 75 (12) | 0.21 |
MAPSE, mm | 18 ± 4.3 | 15 ± 2.9 | 0.002 |
LVEF, % | 72 (7.2) | 72 (7.8) | 0.28 |
LVSVi, ml | 41 (15) | 40 (15) | 0.71 |
RVEDVi, ml | 99 (19) | 83 (21) | < 0.001 |
TAPSE, mm | 23 ± 3.7 | 23 ± 3.9 | 0.58 |
RVEF, % | 58 ± 4.3 | 60 ± 5.2 | 0.068 |
12-lead ECG | |||
RR, ms | 929 ± 139 | 941 ± 133 | 0.75 |
PR, ms | 160 ± 23 | 174 ± 37 | 0.06 |
QRS, ms | 94 ± 8.6 | 100 ± 15 | 0.03 |
QTc, ms | 410 ± 20 | 422 ± 26 | 0.001 |
ECGI parameters | |||
Amp, mV | 1.41 ± 0.34 | 1.41 ± 0.37 | 0.97 |
AT, ms | 41 (10) | 44 (7.7) | 0.30 |
RT, ms | 289 ± 20 | 296 ± 21 | 0.002 |
ARI, ms | 235 ± 18 | 250 ± 21 | 0.002 |
ATd, ms | 11 (3.5) | 13.6 (4.4) | 0.01 |
RTd, ms | 28 (8.9) | 31 (13) | 0.09 |
ARId, ms | 32 ± 9.0 | 37 ± 12 | 0.04 |
GAT, ms/mm | 0.34 (0.12) | 0.40 (0.13) | 0.01 |
GRT, ms/mm | 0.77 (0.23) | 0.92 (0.40) | 0.03 |
GARI, ms/mm | 0.92 ± 0.27 | 1.12 ± 0.40 | 0.01 |
Frac, n | 1.004 (0.01) | 1.003 (0.01) | 0.88 |
Feasibility and time to deploy
Repeatability studies
Repeatability parameter | Intra-observer | Inter-observer |
---|---|---|
rsUEG | 0.99 (0.97–1.00) | 0.98 (0.94–1.00) |
rsAT | 0.88 (0.79–0.93) | 0.86 (− .70–0.88) |
rsRT | 0.83 (0.81–0.89) | 0.76 (0.72–0.85) |
rsARI | 0.80 (0.79–0.87) | 0.75 (0.71–0.81) |
iccUEG | 0.93 (0.83–0.98) | 0.92 (0.81–0.97) |
iccAT | 0.93 (0.85–0.96) | 0.88 (0.75–0.90) |
iccRT | 0.90 (0.87–0.92) | 0.83 (0.80–0.91) |
iccARI | 0.90 (0.85–0.93) | 0.85 (0.81–0.90) |
∆AT, ms | 1.25 (0.42–2.50) | 1.25 (0.42–3.33) |
∆RT, ms | 2.08 (0.83–4.58) | 2.08 (0.83–6.25) |
∆ARI, ms | 2.08 (0.83–5.00) | 2.50 (0.83–7.50) |
∆AT, % | 0.91 (0.34–2.04) | 1.15 (0.43–2.64) |
∆RT, % | 0.54 (0.21–1.24) | 0.62 (0.23–1.75) |
∆ARI, % | 0.84 (0.34–2.11) | 1.13 (0.41–3.28) |