nach oben

Erschienen in:

2014 | OriginalPaper | Buchkapitel

6. Suchtaspekte bei Adipositas

verfasst von : F. Kiefer, M. Grosshans

Erschienen in: Verhaltenssüchte

Verlag: Springer Berlin Heidelberg

Einloggen, um Zugang zu erhalten

Zusammenfassung

Sowohl auf phänomenologischer als auch auf neurobiologischer Ebene bestehen Gemeinsamkeiten zwischen bestimmten Aspekten der Adipositas und klassischen Suchterkrankungen. Adipöse wie Suchtkranke führen süchtiges Verhalten oft trotz Wissen um die negativen Konsequenzen fort und Verhaltensänderungen führen meist zu Rückfällen in alte Verhaltensmuster. Zu berücksichtigen ist allerdings, dass die Belohnungsfunktion von Nahrung auch von homöostatischen Mechanismen beeinflusst wird, insbesondere dem Sättigungsgrad. Im vorliegenden Artikel werden die neurobiologischen Gemeinsamkeiten im Zusammenhang mit dem mesolimbischen, dopaminergen Belohnungssystem diskutiert; bildgebende, neuroendokrine und genetische Untersuchungsansätze dargestellt. Die zunehmende Erhöhung der Inzidenz der Adipositas macht es notwendig, innovative Therapieansätze zu definieren. Eine simplifizierende Differenzierung „Sucht: Ja/Nein“ ist bei einem komplexen Krankheitsbild wie der Adipositas nicht zielführend.

Al’Absi M, Hooker S, Fujiwara K et al. (2011) Circulating leptin levels are associated with increased craving to smoke in abstinent smokers. Pharmacol Biochem Behav 97: 509–513PubMedCrossRef

Albayrak Ö, Wölfle S, Hebebrand J (2012) Does food addiction exist? A phenomenological discussion based on the Psychiatric Classification of Substance-Related Disorders and Addiction. Obesity Facts 5: 165–179PubMedCrossRef

Al Marzooqi MA, Nagy MC (2011) Childhood Obesity Intervention Programs: a systematic review. Life Sci J 8: 46

Barkin SL, Heerman WJ, Warren MD, Rennhoff C (2010) Millennials and the world of work: the impact of obesity on health and productivity. J Bus Psychol 25: 239–245PubMedCentralPubMedCrossRef

Blum K, Noble EP, Sheridan PJ et al. (1990) Allelic association of human D2 receptor gene in alcoholism. JAMA 263: 2055–2060PubMedCrossRef

Blum K, Braverman ER, Wood RC et al. (1996) Increased prevalence of the Taq I A1 allele of the dopamine receptor gene (DRD2) in obesity with comorbid substance use disorder: a preliminary report. Pharmacogenetics 6: 297–305PubMedCrossRef

Charney E, Goodman HC, McBride M et al. (1976) Childhood antecedents of adult obesity. Do chubby infants become obese adults? N Engl J Med 295: 6–9PubMedCrossRef

Daviglus ML, Liu K, Yan LL (2003) Body mass index in middle age and health related quality of life in older age: the Chicago Heart Association Detection Project in Industry Study. Arch Intern Med 163: 2448–2455PubMedCrossRef

Daviglus ML, Liu K, Yan LL (2004) Relation of body mass index in young adulthood and middle age to Medicare expenditures in older age. JAMA 292: 2743–2749PubMedCrossRef

Day JJ, Roitman MF, Wightman RM et al. (2007) Associative learning mediates dynamic shifts in dopamine signaling in the nucleus accumbens. Nat Neurosci 10: 1020–1028PubMedCrossRef

De Zwaan M (2010) Obesity: is it an eating disorder? Psychother Psychosom Med Psychol 60: e1–2PubMedCrossRef

De Zwaan M (2012) Was wenn operative Eingriffe die Psychopathologie langfristig besser beeinflussen könnten als evidenzbasierte Psychotherapie? Pro und Contra bariatrische Chirurgie in der Adipositasbehandlung. Verhaltenstherapie 22: 199–203CrossRef

De Zwaan M, Petersen I, Kaerber M, Burgmer R et al. (2009) Obesity and quality of life: a controlled study of normal-weight and obese individuals. Psychosomatics 50: 474–482

De Zwaan M, Gruss B, Müller A et al. (2011a) Association between obesity and adult attention-deficit/hyperactivity disorder in a German community-based sample. Obes Facts 4 (3): 204–211

De Zwaan M, Enderle J, Wagner S et al. (2011b) Anxiety and depression in bariatric surgery patients: a prospective, follow-up study using structured clinical interviews. J Affect Disord 133 (1–2): 61–68

Di Chiara GT, Bassareo V, Pontieri F (1999) Drug addiction as a disorder of associative learning. Role of nucleus accumbens shell/extended amygdala dopamine. Ann N Y Acad Sci 29: 461–485CrossRef

Dorsey KB, Wells, C, Krumholz HM, Concato JC (2005) Diagnosis, evaluation, and treatment of childhood obesity in pediatric practice. Arch Pediatr Adolesc Med 59: 632–638CrossRef

Elmquist JK, Elias CF, Saper CB (1999) From lesions to leptin: hypothalamic control of food intake and body weight. Neuron 22: 221–232PubMedCrossRef

Epstein LH, Temple JL, Neaderhiser BJ et al. (2007) Food reinforcement, the dopamine D2 receptor genotype, and energy intake in obese and nonobese humans. Behav Neurosci 121: 877–886PubMedCentralPubMedCrossRef

Fernández Meré LA, Alvarez Blanco M (2004) Obesity and bariatric surgery: anesthesia implications. Nutr Hosp 19: 34–44

Flier JS (2004) Obesity wars: molecular progress confronts an expanding epidemic. Cell 116: 337–350PubMedCrossRef

Fulton S, Woodside B, Shizgai P (2000) Modulation on brain reward circuitry by leptin. Science 287: 125–128PubMedCrossRef

Goldbacher EM, Grunwald HE, Lagrotte CA et al. (2012) Factor structure of the emotional eating scale in overweight and obese adults seeking treatment. Appetite 59 (2): 610–615PubMedCentralPubMedCrossRef

Grosshans M, Löber S, Kiefer F (2010) Towards a better understanding of obesity: Implications from addiction research. Addiction Biology 16: 189–198.CrossRef

Grosshans M, Vollmert C, Vollstädt-Klein S et al. (2012) Association of leptin with food cue-induced activation in human reward pathways. Arch Gen Psychiatry 69 (5): 529–537PubMedCrossRef

Hebebrand J, Bammann K, Hinney A (2012) Genetic determinants of obesity [Genetische Marker der Adipositas]. Current issues. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 53: 674–680CrossRef

Hedley AA, Ogden CL, Johnson CL et al. (2004) Prevalence of overweight and obesity among US children, adolescents, and adults, 1999–2002. JAMA 29: 2847–2850CrossRef

Herbert A, Gerry NP, McQueen MB et al. (2006) A common genetic variant is associated with adult and childhood obesity. Science 312: 279–283PubMedCrossRef

Hernandez L, Hoebel BG (1988) Feeding and hypothalamic stimulation increase dopamine turnover in the accumbens. Physiol Behav 44: 599–606PubMedCrossRef

Hommel JD, Trinko R, Sears RM et al. (2006) Leptin receptor signaling in midbrain dopamine neurons regulates feeding. Neuron 51: 801–810PubMedCrossRef

Hyman SE, Malenka RC, Nestler EJ (2006) Neuronal mechanisms of addiction: the role of reward-related learning and memory. Ann Rev Neurosci 29: 565–598.PubMedCrossRef

Kiefer F, Jahn H, Schick M, Wiedemann K (2001) Leptin as a possible modulator of craving for alcohol. Arch Gen Psychiatry 58: 509–510PubMedCrossRef

Konnopka A, Bodemann M, Konig HH (2011) Health burden and costs of obesity and overweight in Germany. Research Support, Non-U.S. Gov’t. Eur J Health Econ 12: 345–352PubMedCrossRef

Krügel U, Schraft T, Kittner H et al. (2003) Basal and feeding-evoked dopamine-release in the rat nucleus accumbens is depressed by leptin. Eur J Pharmacol. 482: 185–187PubMedCrossRef

Kurth BM, Schaffrath Rosario A (2007) The prevalence of overweight and obese children and adolescents living in Germany. Results of the German Health Interview and Examination Survey for Children and Adolescents. Bundesgesundheitsblatt 50: 736–743CrossRef

Leddy JJ, Epstein LH, Jaroni JL et al. (2004) The influence of methylphenidate on eating in obese men. Obesity Research 12: 224–232PubMedCrossRef

Legenbauer T, De Zwaan M, Benecke A (2009) Depression and anxiety: their predictive function for weight loss in obese individuals. Obes Facts 2: 227–2234PubMedCrossRef

Li MF, Cheung BM (2011) Rise and fall of anti-obesity drugs. World J Diabetes 2: 19–23PubMedCentralPubMedCrossRef

Loeber S, Grosshans M, Korucuoglu O et al. (2012) Impairment of inhibitory control in response to food-associated cues and attentional bias of obese patients and normal-weight controls. Int J Obesity 36: 1334–1339CrossRef

Loos RJ, Lindgren CM, Li S, Wheeler E et al. (2008) Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 40: 768–775PubMedCentralPubMedCrossRef

Luepker RV, Murray DM, Jacobs DR et al. (1996) Community education for cardiovascular disease prevention: risk factor changes in the Minnesota Heart Health Program. Am J Public Health 84: 1383–1393CrossRef

Magard MA, Shugarman LR, Suttorp M et al. (2005) Meta-analysis: surgical treatment of obesity. Ann Intern Med 142: 547–559CrossRef

Moreno C, Tandon R (2011) Should overeating and obesity be classified as an addictive disorder in DSM-5? Curr Pharm Des 17: 1128–1131PubMedCrossRef

Mutschler J, Kiefer F (2010) The natriuretic peptide system as a possible therapeutic target for stress-induced obesity. Medical Hypotheses 76: 388–390PubMedCrossRef

Pinto S, Roseberry AG, Liu H et al. (2004) Rapid rewriting of arcuat nucleus feeding circuits by leptin. Science 304: 110–115PubMedCrossRef

Prugger C, Keil U (2007) Development of obesity in Germany – prevalences, determinants and perspectives. Dtsch Med Wochenschrift 132: 892–897CrossRef

Ritchie T, Noble EP (2003) Association of seven polymorphisms of the D2 dopamine receptor gene with brain receptor-binding characteristics. Neurochem Res 28 (1): 73–82PubMedCrossRef

Rothemund Y, Preuschhof C, Bohner G et al. (2007) Differential activation of the dorsal striatum by high-calorie visual food stimuli in obese individuals. Neuroimage 37: 410–421PubMedCrossRef

Samat A, Tomlinson B, Taheri S, Thomas GN (2008) Rimonabant for the treatment of obesity. Recent Pat Cardiovasc Drug Discov 3: 187–193PubMedCrossRef

Scuteri A, Sanna S, Chen WM et al. (2007) Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 3: e115PubMedCentralPubMedCrossRef

Small DM, Zatorre RJ, Dagher A et al. (2001) Changes in brain activity related to eating chocolate: from pleasure to aversion. Brain124: 1720–1733

Small DM, Jones-Gotman M, Dagher A (2003) Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers. Neuroimage 19: 1709–1715PubMedCrossRef

Speliotes EK, Willer CJ, Berndt SI et al. (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 42: 937–948PubMedCentralPubMedCrossRef

Stice E, Spoor S, Bohon C, Small DM (2008) Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 Allele. Science 322: 449–452PubMedCrossRef

Swinburn B, Gill T, Kumanyika S (2005) Obesity Prevention: a proposed framework for translating evidence into action. Obesity reviews 6: 22–33

Swinburn BA, Sacks G, Hall KD et al. (2011) The global obesity pandemic: shaped by global drivers and local environments. Lancet 378: 804–814PubMedCrossRef

Topol EJ, Bousser MG, Fox KA et al. (2010) Rimonabant for prevention of cardiovascular events (CRESCENDO): a randomised, multicentre, placebo-controlled trial. Lancet. 14: 517–523CrossRef

Volkow ND, O´Brien CP (2007) Issues for DSM-V: should obesity be included as a brain disorder? J Psychiatry 164: 708–710

Volkow ND, Wang GJ, Telang F et al. (2008) Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: Possible contributing factors. Neuroimage 42: 1537–1543PubMedCentralPubMedCrossRef

Volkow ND, Wang GJ, Fowler JS et al. (2012) Food and drug reward: Overlapping Circuits in Human Obesity and addiction. Curr Top Behav Neurosci 11: 1–24PubMedCrossRef

Von der Goltz C, Kiefer F (2009) Learning and memory in the etiopathogenesis of addiction: future implications for therapy? Eur Arch Psychiatry Clin Neurosci 259: 183–187CrossRef

Von der Goltz C, Koopmann A, Dinter C et al. (2010) Orexin and leptin are associated with nicotine craving: a potential link between smoking, appetite and reward. Psychoneuroendocrinology 35: 570–577

Wang GJ, Volkow ND, Logan J et al. (2001) Brain dopamine and obesity. Lancet 3: 354–357CrossRef

Wang GJ, Volkow ND, Thanos PK, Fowler JS (2004) Similarity between obesity and drug addiction as assessed by neurofunctional imaging: a concept review J Addict Dis 23: 39–53PubMedCrossRef

Wang YC, McPherson K, Marsh T et al. (2011) Health and economic burden of the projected obesity trends in the USA and the UK. Comment Research Support, Non-U.S. Gov’t Research Support, U.S. Gov’t, P.H.S. Lancet 378: 815–825PubMedCrossRef

Wellman PJ (2005) Modulation of eating by central catecholamine systems. Current Drug Targets 6: 191–199PubMedCrossRef

Yan LL, Daviglus ML, Liu K et al. (2006) Midlife body mass index and hospitalization and mortality in older age. JAMA 295: 190–198PubMedCrossRef

Ziauddeen H, Farooqi IS, Fletcher PC (2012) Obesity and the brain: how convincing is the addiction model? Nat Rev Neurosci 14: 279–286

Titel: Suchtaspekte bei Adipositas
verfasst von: F. Kiefer
M. Grosshans
Verlag: Springer Berlin Heidelberg
Buch: Verhaltenssüchte
Print ISBN: 978-3-642-38363-2

Electronic ISBN: 978-3-642-38364-9

Copyright-Jahr: 2014
DOI: https://doi.org/10.1007/978-3-642-38364-9_6

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

6. Suchtaspekte bei Adipositas

Zusammenfassung

Neu im Fachgebiet Psychiatrie

Hörschwäche erhöht Demenzrisiko unabhängig von Beta-Amyloid

So wirken verschiedene Alkoholika auf den Blutdruck

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

ADHS-Medikation erhöht das kardiovaskuläre Risiko

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Zusammenfassung

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Neu im Fachgebiet Psychiatrie

Hörschwäche erhöht Demenzrisiko unabhängig von Beta-Amyloid

So wirken verschiedene Alkoholika auf den Blutdruck

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

ADHS-Medikation erhöht das kardiovaskuläre Risiko