Introduction
Methods
Study design and patient selection
Uteroplacental Doppler flow measurements
CMR imaging
CMR analysis
Statistical analysis
Results
Pre-pregnancy characteristics
Total n = 31 | |
---|---|
Maternal age at conception (years) | 30.0 ± 4.8 |
BMI (kg/m2) | 24.6 ± 4.3 |
NYHA class | |
I | 21 (67.7%) |
II | 10 (32.3%) |
Modified WHO classa | |
II | 25 (80.6%) |
III | 6 (19.4%) |
Surgical history | |
Age complete ToF repair | 2 [1–5 years] |
Type of ToF repair | |
Infundibular patch / commissurotomy | 13 (41.9%) |
Transannular patch | 12 (38.7%) |
RV-pulmonary artery conduit | 2 (6.5%) |
Other | 4 (12.9%) |
Pulmonary valve replacement | 8 (25.8%) |
Total n = 31 | |
---|---|
RV mass index (g/m2) | 30.5 ± 7.4 |
RV end-diastolic volume index (ml/m2) | 119.0 ± 32.5 |
RV end-systolic volume index (ml/m2) | 61.9 ± 23.0 |
RV cardiac output (L/min) | 4.7 ± 0.9 |
RV ejection fraction (%) | 49.0 ± 7.7 |
RV dysfunction (EF < 45%) | 9 (29.0%) |
RV/LV volume ratio | 1.5 ± 0.6 |
LV mass index (g/m2) | 42.2 ± 11.1 |
LV end-diastolic volume index (ml/m2) | 79.6 ± 18.1 |
LV end-systolic volume index (ml/m2) | 34.1 ± 11.7 |
LV cardiac output (L/min) | 4.8 ± 0.8 |
LV ejection fraction (%) | 57.8 ± 5.9 |
LV dysfunction (EF < 50%) | 2 (6.5) |
Pulmonary regurgitation fraction (%) | 24.7 ± 19.3 |
Relationship between pre-pregnancy CMR parameters and uteroplacental circulation
N | Beta (95% CI) | P-value | |
---|---|---|---|
Univariable | |||
Age at conception | 26 | −0.007 (− 0.044–0.030) | 0.687 |
BMI (kg/m2) | 26 | − 0.018 (− 0.053–0.017) | 0.299 |
Parity | 26 | −0.048 (− 0.370–0.284) | 0.788 |
RV mass index (g/m2) | 26 | 0.002 (− 0.019–0.023) | 0.874 |
RV EDVI (mL/m2) | 26 | 0.004 (− 0.003–0.010) | 0.270 |
RV ESVI (mL/m2) | 26 | 0.008 (− 0.001–0.016) | 0.064 |
RV cardiac output (L/min) | 25 | −0.026 (− 0.167–0.115) | 0.707 |
RVEF (%) | 26 | − 0.021 (− 0.041 – − 0.001) | 0.037 |
RV/LV volume ratio | 26 | − 0.267 (− 0.730–0.197) | 0.247 |
LV mass index (g/m2) | 26 | 0.006 (− 0.013–0.025) | 0.509 |
LV EDVI (mL/m2) | 26 | 0.015 (0.007–0.023) | 0.001 |
LV ESVI (mL/m2) | 26 | 0.018 (0.007–0.030) | 0.003 |
LV cardiac output (L/min) | 23 | − 0.047 (− 0.277–0.182) | 0.671 |
LVEF (%) | 26 | − 0.019 (− 0.043–0.006) | 0.126 |
Multivariable | |||
RVEF adjusted for age | 26 | −0.008 (− 0.042 – − 0.001) | 0.040 |
RVEF adjusted for age and BMI | 26 | − 0.020 (− 0.041–0.001) | 0.057 |
N | Beta (95% CI) | P-value | |
---|---|---|---|
Univariable | |||
Age at conception | 28 | 0.015 (0.001–0.030) | 0.037 |
BMI (kg/m2) | 28 | −0.014 (− 0.030–0.001) | 0.071 |
Parity | 28 | 0.045 (− 0.103–0.194) | 0.536 |
RV mass index (g/m2) | 28 | 0.002 (− 0.008–0.012) | 0.655 |
RV EDVI (mL/m2) | 28 | 0.002 (0.000–0.005) | 0.057 |
RV ESVI (mL/m2) | 28 | 0.005 (0.002–0.008) | 0.004 |
RV cardiac output (L/min) | 27 | −0.029 (− 0.092–0.034) | 0.347 |
RVEF (%) | 28 | − 0.015 (− 0.023 – − 0.006) | 0.001 |
RV/LV ratio | 28 | 0.079 (− 0.051–0.208) | 0.222 |
LV mass index (g/m2) | 28 | 0.001 (− 0.006–0.008) | 0.752 |
LV EDVI (mL/m2) | 28 | 0.001 (− 0.004–0.005) | 0.778 |
LV ESVI (mL/m2) | 28 | 0.002 (− 0.005–0.008) | 0.582 |
LV cardiac output (L/min) | 24 | −0.025 (− 0.116–0.067) | 0.581 |
LVEF (%) | 28 | − 0.006 (− 0.019–0.006) | 0.305 |
Multivariable | |||
RVEF adjusted for age | 28 | −0.014 (− 0.021 – − 0.006) | 0.001 |
RVEF adjusted for age and BMI | 28 | − 0.013 (− 0.020 – − 0.005) | 0.002 |