Background
Methods
Patient population
Cardiovascular magnetic resonance
Feature-tracking cardiovascular magnetic resonance analysis
Definition of infarct zone and remote zone myocardium
Study endpoints
Statistical analysis
Results
Infarct zone circumferential strain (%) | Remote zone circumferential strain (%) | |||||||
---|---|---|---|---|---|---|---|---|
1 week | 6 months | MD [95% CI] | P-value* | 1 week | 6 months | MD [95% CI] | P-value* | |
Metoprolol (N = 97) | −9.9 ± 7.6 | − 15.7 ± 7.5 | −5.7 [− 6.8 to − 4.6] | < 0.001 | −19.7 ± 3.6 | − 19.2 ± 4.1 | 0.6 [− 0.2 to 1.3] | 0.153 |
Control (N = 94) | −7.2 ± 10.1 | −13.2 ± 8.3 | −6.0 [− 7.7 to − 4.2] | < 0.001 | − 19.3 ± 7.5 | − 19.3 ± 3.7 | 0.0 [− 1.4 to 1.4] | 0.984 |
MD [95% CI] | −2.7 [− 5.3 to − 0.1] | −2.5 [− 4.7 to − 0.2] | −0.5 [− 2.1 to 1.2] | 0.1 [− 1.0 to 1.2] | ||||
P-value† | 0.038 | 0.033 | 0.589 | 0.876 |
Evolution of infarct and remote zone circumferential strain
The effect of early intravenous metoprolol on infarct and remote zone circumferential strain
The effect of MVO and IMH on infarct and remote zone circumferential strain
Infarct zone circumferential strain (%) | Remote zone circumferential strain (%) | |||||||
---|---|---|---|---|---|---|---|---|
1 week | 6 months | MD [95% CI] | P-value* | 1 week | 6 months | MD [95% CI] | P-value* | |
MVO (N = 117) | − 5.1 ± 8.8 | −11.2 ± 7.8 | −6.2 [− 7.7 to − 4.7] | < 0.001 | − 19.3 ± 7.0 | − 19.2 ± 3.8 | 0.1 [− 1.0 to 1.3] | 0.828 |
No MVO (N = 73) | −14.2 ± 6.1 | − 19.5 ± 5.1 | − 5.3 [− 6.5 to − 4.1] | < 0.001 | − 19.7 ± 3.4 | −19.2 ± 4.2 | 0.5 [− 0.5 to 1.5] | 0.313 |
MD [95% CI] | 9.2 [6.9 to 11.5] | 8.3 [6.5 to 10.2] | 0.4 [−1.4 to 2.1] | 0.0 [−1.2 to 1.1] | ||||
P-value† | < 0.001 | < 0.001 | 0.677 | 0.981 |
Infarct zone circumferential strain (%) | Remote zone circumferential strain (%) | |||||||
---|---|---|---|---|---|---|---|---|
1 week | 6 months | MD [95% CI] | P-value* | 1 week | 6 months | MD [95% CI] | P-value* | |
IMH (N = 81) | −4.1 ± 9.4 | −10.5 ± 7.8 | −6.4 [−8.3 to − 4.4] | < 0.001 | −19.2 ± 7.7 | − 19.3 ± 3.7 | −0.2 [− 1.7 to 1.4] | 0.852 |
No IMH (N = 110) | − 11.9 ± 7.1 | −17.4 ± 6.8 | −5.5 [− 6.5 to − 4.4] | < 0.001 | −19.8 ± 4.0 | − 19.1 ± 4.1 | 0.6 [− 0.1 to 1.4] | 0.102 |
MD [95% CI] | 7.8 [5.5 to 10.2] | 6.9 [4.8 to 9.0] | 0.6 [−1.1 to 2.3] | −0.2 [− 1.3 to 0.9] | ||||
P-value† | < 0.001 | < 0.001 | 0.504 | 0.736 |
The effect of adverse LV remodeling on infarct and remote zone circumferential strain
Infarct zone circumferential strain (%) | Remote zone circumferential strain (%) | |||||||
---|---|---|---|---|---|---|---|---|
1 week | 6 months | MD [95% CI] | P-value* | 1 week | 6 months | MD [95% CI] | P-value* | |
LV remodeling (N = 52) | − 7.6 ± 8.2 | −12.6 ± 9.4 | −5.0 [−6.6 to − 3.4] | < 0.001 | − 20.2 ± 3.7 | −19.1 ± 3.7 | 1.1 [0.1 to 2.1] | 0.036 |
No LV remodeling (N = 139) | −9.0 ± 9.3 | −15.1 ± 7.3 | −6.2 [− 7.4 to − 4.9] | < 0.001 | −19.2 ± 6.5 | − 19.3 ± 4.0 | 0.0 [− 1.0 to 1.0] | 0.991 |
MD [95% CI] | 1.3 [−1.6 to 4.2] | 2.5 [−0.4 to 5.4] | −1.0 [− 2.8 to 0.9] | 0.1 [− 1.1 to 1.4] | ||||
P-value† | 0.366 | 0.087 | 0.317 | 0.822 |