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2014 | OriginalPaper | Buchkapitel

7. Neurobiologische und genetische Befunde bei pathologischem Glücksspiel

verfasst von : M. Fauth-Bühler, N. Romanczuk-Seiferth, K. Mann, A. Heinz

Erschienen in: Verhaltenssüchte

Verlag: Springer Berlin Heidelberg

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Zusammenfassung

Die neurobiologischen Grundlagen von stoffgebundenen Süchten sind gut untersucht. In den letzten Jahren hat sich jedoch auch die Befundlage zu den neurobiologischen Grundlagen von Verhaltenssüchten und insbesondere vom pathologischem Glücksspiel zunehmend verbessert. Dieses Kapitel gibt einen Überblick über den aktuellen Stand der Forschung bei pathologischem Glücksspiel. Dabei werden Erkenntnisse, die mittels verschiedener moderner bildgebenden Verfahren sowie elektrophysiologischer Methoden gewonnen wurden, wie auch genetische Befunde zusammenfassend dargestellt. Die Ergebnisse deuten auf Veränderungen in den Hirnfunktionen als auch der Hirnstrukturen bei pathologischen Spielern im Vergleich zu gesunden Kontrollen hin. Wie auch bei stoffgebunden Süchten spielt das dopaminerge mesokortikolimbische Belohnungssystem eine Schlüsselrolle bei der Entstehung und Aufrechterhaltung der „Glücksspielsucht“.

Balodis IM, Kober H, Worhunsky PD et al. (2012) Diminished frontostriatal activity during processing of monetary rewards and losses in pathological gambling. Biol Psychiatry 71: 749–757PubMedCentralPubMedCrossRef

Blanco C, Orensanz-Muñoz L, Blanco-Jerez C et al. (1996) Pathological gambling and platelet MAO activity: a psychobiological study. Am J Psychiatry 153: 119–121PubMed

Boileau I, Payer D, Chugani B et al. (2013a) The D2/3 dopamine receptor in pathological gambling: a positron emission tomography study with [11C]-(+)-propyl-hexahydro-naphtho-oxazin and [11C]raclopride. Addiction 108, 953–63. doi:10.1111/add.12066PubMedCrossRef

Boileau I, Payer D, Chugani B et al. (2013b) In vivo evidence for greater amphetamine-induced dopamine release in pathological gambling: a positron emission tomography study with [(11)C]-(+)-PHNO. Mol Psychiatry doi:10.1038/mp.2013.163

Bühler M, Mann K (2011) Alcohol and the human brain: a systematic review of different neuroimaging methods. Alcohol Clin Exp Res 35: 1771–1793. doi:10.1111/j.1530-0277.2011.01540.xPubMedCrossRef

Bühler M, Vollstädt-Klein S, Kobiella A et al. (2010) Nicotine dependence is characterized by disordered reward processing in a network driving motivation. Biol Psychiatry 67: 745–752. doi:10.1016/j.biopsych.2009.10.029PubMedCrossRef

Clark L, Limbrick-Oldfield EH (2013) Disordered gambling: a behavioral addiction. Curr Opin Neurobiol 23: 655–659PubMedCrossRef

Clark L, Stokes PR, Wu K, Michalczuk R et al. (2012) Striatal dopamine Dâ/Dâ receptor binding in pathological gambling is correlated with mood-related impulsivity. Neuroimage 63: 40–46. doi:10.1016/j.neuroimage.2012.06.067PubMedCentralPubMedCrossRef

Comings D, Gade-Andavolu R, Gonzalez N et al. (2001) The additive effect of neurotransmitter genes in pathological gambling. Clin Genet 60: 107–116. doi:10.1034/j.1399-0004.2001.600204.xPubMedCrossRef

Crockford DN, Goodyear B, Edwards J et al. (2005) Cue-Induced Brain Activity in Pathological Gamblers. Biol Psychiatry 58: 787–795PubMedCrossRef

De Greck M, Enzi, Prösch U et al. (2010) Decreased neuronal activity in reward circuitry of pathological gamblers during processing of personal relevant stimuli. Hum Brain Mapp 31: 1802–1812. doi:10.1002/hbm.20981PubMed

De Ruiter MB, Veltman DJ, Goudriaan AE et al. (2009) Response perseveration and ventral prefrontal sensitivity to reward and punishment in male problem gamblers and smokers. Neuropsychopharmacology 34: 1027–1038. doi:10.1038/npp.2008.175PubMedCrossRef

Dymond S, Lawrence NS, Dunkley BT et al. (2014) Almost winning: induced MEG theta power in insula and orbitofrontal cortex increases during gambling near-misses and is associated with BOLD signal and gambling severity. Neuroimage. doi:10.1016/j.neuroimage.2014.01.019

Goldstein L, Carlton P (1988) Hemispheric EEG correlates of compulsive behavior: The case of pathological gamblers. Res Commun Psychol Psychiatr Behav 13: 103–111

Goldstein L, Manowitz P, Nora R et al. (1985) Differential EEG activation and pathological gambling. Biol Psychiatry 20: 1232–1234PubMedCrossRef

Goudriaan AE, de Ruiter MB, van den Brink W et al. (2010) Brain activation patterns associated with cue reactivity and craving in abstinent problem gamblers, heavy smokers and healthy controls: an fMRI study. Addict Biol 15: 491–503. doi:10.1111/j.1369-1600.2010.00242.xPubMedCentralPubMedCrossRef

Gyollai A, Griffiths M, Barta C et al. (2014) The genetics of problem and pathological gambling: a systematic review. Curr Pharm Des 20 (25): 3993–3999PubMedCrossRef

Heinz A, Beck A, Grüsser SM et al. (2009) Identifying the neural circuitry of alcohol craving and relapse vulnerability. Addict Biol 14: 108–118. doi:101111/j.1369-1600.2008.00136.xPubMedCentralPubMedCrossRef

Hewig J, Kretschmer N, Trippe RH et al. (2010) Hypersensitivity to reward in problem gamblers. Biol Psychiatry 67: 781–783. doi:10.1016/j.biopsych.2009.11.009PubMedCrossRef

Hollander E, Pallanti S, Baldini Rossi N et al. (2005) Imaging monetary reward in pathological gamblers. World J Biol Psychiatry 6: 113–120PubMedCrossRef

Joutsa J, Johansson J, Niemelä S et al. (2012) Mesolimbic dopamine release is linked to symptom severity in pathological gambling. Neuroimage 60: 1992–1999. doi:10.1016/j.neuroimage.2012.02.006PubMedCrossRef

Joutsa J, Saunavaara J, Parkkola R et al. (2011) Extensive abnormality of brain white matter integrity in pathological gambling. Psychiatry Res 194: 340–346 doi:10.1016/j.pscychresns.2011.08.001PubMedCrossRef

Knutson B, Fong G, Adams C et al. (2001) Dissociation of reward anticipation and outcome with event-related fMRI. Neuroreport 12: 3683–3687PubMedCrossRef

Koehler S, Hasselmann E, Wüstenberg T et al. (2013a) Higher volume of ventral striatum and right prefrontal cortex in pathological gambling. Brain Struct Funct. doi:10.1007/s00429-013-0668-6

Koehler S, Ovadia-Caro S, van der Meer E et al. (2013b) Increased Functional Connectivity between Prefrontal Cortex and Reward System in Pathological Gambling. PLoS One 8, e84565. doi:10.1371/journal.pone.0084565PubMedCentralPubMedCrossRef

Leeman R, Potenza M (2013) A targeted review of the neurobiology and genetics of behavioural addictions: an emerging area of research. Can J Psychiatry 58: 260–273PubMedCentralPubMed

Limbrick-Oldfield EH, van Holst RJ, Clark L (2013) Fronto-striatal dysregulation in drug addiction and pathological gambling: Consistent inconsistencies? NeuroImage Clin 2: 385–393. doi:10.1016/j.nicl.2013.02.005PubMedCentralPubMedCrossRef

Lin SAEN, Lyons MJ, Scherrer JF et al. (1998) Familial influences on gambling behavior: an analysis of 3359 twin pairs. Addiction 93: 1375–1384. doi:10.1046/j.1360-0443.1998.93913758.xPubMedCrossRef

Lind PA, Zhu G, Montgomery GW et al. (2013) Genome-wide association study of a quantitative disordered gambling trait. Addict Biol 18: 511–522. doi:10.1111/j.1369-1600.2012.00463.xPubMedCentralPubMedCrossRef

Linnet J, Mouridsen K, Peterson E et al. (2012) Striatal dopamine release codes uncertainty in pathological gambling. Psychiatry Res 204: 55–60. doi:10.1016/j.pscychresns.2012.04.012PubMedCrossRef

Lobo D, Kennedy J (2006) The genetics of gambling and behavioral addictions. CNS Spectr 11: 931–939PubMed

Mann K, Fauth-Bühler M, Seiferth N, Heinz A (2013) The concept of behavioral addiction and limits of the term addiction. Nervenarzt 84: 548–556. doi:10.1007/s00115-012-3718-zPubMedCrossRef

Miedl SF, Fehr T, Meyer G, Herrmann M (2010) Neurobiological correlates of problem gambling in a quasi-realistic blackjack scenario as revealed by fMRI. Psychiatry Res Neuroimaging 181: 165–173CrossRef

Miedl SF, Peters J, Büchel C (2012) Altered neural reward representations in pathological gamblers revealed by delay and probability discounting. Arch Gen Psychiatry 69: 177–186. doi:10.1001/archgenpsychiatry.2011.1552PubMedCrossRef

Mörsen C, Heinz A, Fauth-Bühler M, Mann K (2011) Glücksspiel im Gehirn: neurobiologische Gundlagen pathologischen Glückspielens. Sucht 57: 259–273CrossRef

Oberg SAK, Christie GJ, Tata MS (2011) Problem gamblers exhibit reward hypersensitivity in medial frontal cortex during gambling. Neuropsychologia 49: 3768–3775. doi:10.1016/j.neuropsychologia.2011.09.037PubMedCrossRef

Potenza M (2003) An fMRI Stroop Task Study of Ventromedial Prefrontal Cortical Function in Pathological Gamblers. Am J Psychiatry 160: 1990–1994. doi:10.1176/appi.ajp.160.11.1990CrossRef

Potenza MN (2008) Review. The neurobiology of pathological gambling and drug addiction: an overview and new findings. Philos Trans R Soc Lond B Biol Sci 363: 3181–3189. doi:10.1098/rstb.2008.0100PubMedCentralPubMedCrossRef

Potenza MN, Steinberg MA, Skudlarski P et al. (2003) Gambling urges in pathological gambling: a functional magnetic resonance imaging study. Arch Gen Psychiatry 60: 828–836. doi:10.1001/archpsyc.60.8.828PubMedCrossRef

Rahman AS, Xu J, Potenza MN (2014) Hippocampal and amygdalar volumetric differences in pathological gambling: a preliminary study of the associations with the behavioral inhibition system. Neuropsychopharmacology 39: 738–745. doi:10.1038/npp.2013.260PubMedCrossRef

Regard M, Knoch D, Gütling E, Landis T (2003) Brain damage and addictive behavior: a neuropsychological and electroencephalogram investigation with pathologic gamblers. Cogn Behav Neurol 16: 47–53PubMedCrossRef

Reuter J, Raedler T, Rose M et al. (2005) Pathological gambling is linked to reduced activation of the mesolimbic reward system. Nat Neurosci 8: 147–148. doi:10.1038/nn1378PubMedCrossRef

Romanczuk-Seiferth N, Koehler S, Dreesen C et al. (2014) Pathological gambling and alcohol dependence: neural disturbances in reward and loss avoidance processing. Addict Biol. doi:10.1111/adb.12144

Shemchuk N, Berezina I, Oshevskiĭ D (2008) Assessment of the brain functional state in pathological gamblers with a complex of neurophysiological methods. Zhurnal Nevrol i psikhiatrii Im SS Korsakova 108: 43–47

Stojanov W, Karayanidis F, Johnston P et al. (2003) Disrupted sensory gating in pathological gambling. Biol Psychiatry 54: 474–484. doi:10.1016/S0006-3223(02)01745-6PubMedCrossRef

Stroop J (1935) Studies of interference in serial verbal reactions. J Exp Psychol 18: 643–662CrossRef

Tanabe J, Thompson L, Claus E et al. (2007) Prefrontal cortex activity is reduced in gambling and nongambling substance users during decision-making. Hum Brain Mapp 28: 1276–1286. doi:10.1002/hbm.20344PubMedCrossRef

Tschernegg M, Crone JS, Eigenberger T et al. (2013) Abnormalities of functional brain networks in pathological gambling: a graph-theoretical approach. Front Hum Neurosci 7: 625. doi:10.3389/fnhum.2013.00625PubMedCentralPubMedCrossRef

Van Holst RJ, van den Brink W, Veltman DJ, Goudriaan AE (2010) Brain imaging studies in pathological gambling. Curr Psychiatry Rep 12: 418–425. doi:10.1007/s11920-010-0141-7PubMedCentralPubMedCrossRef

Van Holst RJ, de Ruiter MB, van den Brink W et (2012a) A voxel-based morphometry study comparing problem gamblers, alcohol abusers, and healthy controls. Drug Alcohol Depend 124: 142–148. doi:10.1016/j.drugalcdep.2011.12.025

Van Holst RJ, van der Meer JN, McLaren DG, et al. (2012b) Interactions between affective and cognitive processing systems in problematic gamblers: a functional connectivity study. PLoS One 7, e49923. doi:10.1371/journal.pone.0049923PubMedCentralPubMedCrossRef

Van Holst RJ, van Holstein M, van den Brink W et (2012c) Response inhibition during cue reactivity in problem gamblers: an fMRI study. PLoS One 7, e30909. doi:10.1371/journal.pone.0030909

Wöfling K, Bühler M, Leménager T, Mörsen C, Mann K (2009) Glücksspiel- und Internetsucht: Review und Forschungsagenda. Nervenarzt 80: 1030–1039CrossRef

Wölfling K, Mörsen CP, Duven E et al. (2011) To gamble or not to gamble: at risk for craving and relapse–learned motivated attention in pathological gambling. Biol Psychol 87: 275–281. doi:10.1016/j.biopsycho.2011.03.010PubMedCrossRef

Wrase J, Schlagenhauf F, Kienast T et al. (2007) Dysfunction of reward processing correlates with alcohol craving in detoxified alcoholics. Neuroimage 35: 787–794PubMedCrossRef

Xian H, Scherrer J, Slutske W et al. (2007) Genetic and environmental contributions to pathological gambling symptoms in a 10-year follow-up. Twin Res Hum Genet 10: 174–179PubMedCrossRef

Yip SW, Lacadie C, Xu J et al. (2013) Reduced genual corpus callosal white matter integrity in pathological gambling and its relationship to alcohol abuse or dependence. World J Biol Psychiatry 14: 129–138. doi:10.3109/15622975.2011.568068PubMedCentralPubMedCrossRef

Titel: Neurobiologische und genetische Befunde bei pathologischem Glücksspiel
verfasst von: M. Fauth-Bühler
N. Romanczuk-Seiferth
K. Mann
A. Heinz
Verlag: Springer Berlin Heidelberg
Buch: Verhaltenssüchte
Print ISBN: 978-3-642-38363-2

Electronic ISBN: 978-3-642-38364-9

Copyright-Jahr: 2014
DOI: https://doi.org/10.1007/978-3-642-38364-9_7

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7. Neurobiologische und genetische Befunde bei pathologischem Glücksspiel

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Live-Webinar "Urologie und Sexualmedizin in der Praxis"

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Zusammenfassung

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Neu im Fachgebiet Psychiatrie

Hörschwäche erhöht Demenzrisiko unabhängig von Beta-Amyloid

So wirken verschiedene Alkoholika auf den Blutdruck

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

ADHS-Medikation erhöht das kardiovaskuläre Risiko