Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Typ-2-Diabetes und Adipositas Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Häufige urologisch-sexualmedizinische Themen in der Praxis sind das Thema des MMW-Webinars am 5. Juni von 17.30 bis 19 Uhr. Konkret geht es um die Frage, wann bei Harnwegsinfektionen auf Antibiotika verzichtet werden kann, und um ein Update zur Therapie von Libido- und Potenzstörungen des Mannes. Der dritte Vortrag behandelt sexuell übertragbare Krankheiten. Stellen Sie Ihre Fragen an die Experten und sammeln Sie 2 CME-Punkte. Jetzt gleich anmelden!
Erweiterte Suche
Anmelden
nach oben
European Journal of Nuclear Medicine and Molecular Imaging
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging 6/2024

01.03.2024 | Editorial

More than meets the eye: 2-[18F]FDG PET-based radiomics predicts lymph node metastasis in colorectal cancer patients to enable precision medicine

verfasst von: Wenpeng Huang, Mai Hong Son, Le Ngoc Ha, Lei Kang, Weibo Cai

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 6/2024

Einloggen, um Zugang zu erhalten

Excerpt

Colorectal cancer (CRC) ranks as the third most prevalent cancer and the fourth leading cause of cancer-related mortality worldwide [1, 2]. Lymph node metastasis (LNM) stands as the primary route of metastasis in CRC, intricately influencing the surgical scope, the formulation of adjuvant chemotherapy programs, and the postoperative survival rates of patients [3, 4]. Consequently, the accurate and comprehensive assessment of lymph node (LN) status is pivotal in CRC, holding the potential to optimize personalized therapy—often referred to as precision medicine—thus advancing individualized patient care. The conventional gold standard for diagnosing LNM involves preoperative invasive lymph node biopsy and pathology. However, the pathological examination has several limitations, including invasiveness, high cost, and susceptibility to sampling errors. …
Literatur
1.
Shinji S, Yamada T, Matsuda A, Sonoda H, Ohta R, Iwai T, et al. Recent advances in the treatment of colorectal cancer: a review. J Nippon Med Sch. 2022;89:246–54.CrossRefPubMed
2.
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136:E359-386.CrossRefPubMed
3.
Li M, Zhang J, Dan Y, Yao Y, Dai W, Cai G, et al. A clinical-radiomics nomogram for the preoperative prediction of lymph node metastasis in colorectal cancer. J Transl Med. 2020;18:46.CrossRefPubMedPubMedCentral
4.
Jin M, Frankel WL. Lymph node metastasis in colorectal cancer. Surg Oncol Clin N Am. 2018;27:401–12.CrossRefPubMed
5.
Nambu A, Kato S, Sato Y, Okuwaki H, Nishikawa K, Saito A, et al. Relationship between maximum standardized uptake value (SUVmax) of lung cancer and lymph node metastasis on FDG-PET. Ann Nucl Med. 2009;23:269–75.CrossRefPubMed
6.
Lee BE, von Haag D, Lown T, Lau D, Calhoun R, Follette D. Advances in positron emission tomography technology have increased the need for surgical staging in non-small cell lung cancer. J Thorac Cardiovasc Surg. 2007;133:746–52.CrossRefPubMed
7.
Flechsig P, Kratochwil C, Schwartz LH, Rath D, Moltz J, Antoch G, et al. Quantitative volumetric CT-histogram analysis in N-staging of 18F-FDG-equivocal patients with lung cancer. J Nucl Med. 2014;55:559–64.CrossRefPubMed
8.
de Koster EJ, Noortman WA, Mostert JM, Booij J, Brouwer CB, de Keizer B, et al. Quantitative classification and radiomics of [18F]FDG-PET/CT in indeterminate thyroid nodules. Eur J Nucl Med Mol Imaging. 2022;49:2174–88.CrossRefPubMedPubMedCentral
9.
Ghezzo S, Mapelli P, Bezzi C, Samanes Gajate AM, Brembilla G, Gotuzzo I, et al. Role of [68Ga]Ga-PSMA-11 PET radiomics to predict post-surgical ISUP grade in primary prostate cancer. Eur J Nucl Med Mol Imaging. 2023;50(8):2548–60.
10.
Mapelli P, Bezzi C, Palumbo D, Canevari C, Ghezzo S, Samanes Gajate AM, et al. 68Ga-DOTATOC PET/MR imaging and radiomic parameters in predicting histopathological prognostic factors in patients with pancreatic neuroendocrine well-differentiated tumours. Eur J Nucl Med Mol Imaging. 2022;49(7):2352–63.
11.
Sollini M, Antunovic L, Chiti A, Kirienko M. Towards clinical application of image mining: a systematic review on artificial intelligence and radiomics. Eur J Nucl Med Mol Imaging. 2019;46:2656–72.CrossRefPubMedPubMedCentral
12.
Mu W, Schabath MB, Gillies RJ. Images are data: challenges and opportunities in the clinical translation of radiomics. Cancer Res. 2022;82:2066–8.CrossRefPubMed
13.
Yoon JH, Kim H. CT Radiomics in oncology: insights into the tumor microenvironment of hepatocellular carcinoma. Radiology. 2023;307: e222988.CrossRefPubMed
14.
15.
Giesel FL, Schneider F, Kratochwil C, Rath D, Moltz J, Holland-Letz T, et al. Correlation between SUVmax and CT radiomic analysis using lymph node density in PET/CT-based lymph node staging. J Nucl Med. 2017;58:282–7.CrossRefPubMed
16.
Cysouw MCF, Jansen BHE, van de Brug T, Oprea-Lager DE, Pfaehler E, de Vries BM, et al. Machine learning-based analysis of [18F]DCFPyL PET radiomics for risk stratification in primary prostate cancer. Eur J Nucl Med Mol Imaging. 2021;48:340–9.CrossRefPubMed
17.
Lei X, Cao Z, Wu Y, Lin J, Zhang Z, Jin J, et al. Preoperative prediction of clinical and pathological stages for patients with esophageal cancer using PET/CT radiomics. Insights Imaging. 2023;14:174.CrossRefPubMedPubMedCentral
18.
Li XR, Jin JJ, Yu Y, Wang XH, Guo Y, Sun HZ. PET-CT radiomics by integrating primary tumor and peritumoral areas predicts E-cadherin expression and correlates with pelvic lymph node metastasis in early-stage cervical cancer. Eur Radiol. 2021;31:5967–79.CrossRefPubMed
19.
Romeo V, Kapetas P, Clauser P, Rasul S, Cuocolo R, Caruso M, et al. Simultaneous 18F-FDG PET/MRI radiomics and machine learning analysis of the primary breast tumor for the preoperative prediction of axillary lymph node status in breast cancer. Cancers (Basel). 2023;15:5088.CrossRefPubMed
20.
Xue XQ, Yu WJ, Shi X, Shao XL, Wang YT. 18F-FDG PET/CT-based radiomics nomogram for the preoperative prediction of lymph node metastasis in gastric cancer. Front Oncol. 2022;12:911168.CrossRefPubMedPubMedCentral
21.
He J, Wang Q, Zhang Y, Wu H, Zhou Y, Zhao S. Preoperative prediction of regional lymph node metastasis of colorectal cancer based on 18F-FDG PET/CT and machine learning. Ann Nucl Med. 2021;35:617–27.CrossRefPubMed
22.
Xie Y, Zhao H, Guo Y, Meng F, Liu X, Zhang Y, et al. A PET/CT nomogram incorporating SUVmax and CT radiomics for preoperative nodal staging in non-small cell lung cancer. Eur Radiol. 2021;31:6030–8.CrossRefPubMedPubMedCentral
23.
Chan KC, Perucho JAU, Subramaniam RM, Lee EYP. Utility of pre-treatment 18 F-fluorodeoxyglucose PET radiomic analysis in assessing nodal involvement in cervical cancer. Nucl Med Commun. 2023;44:375–80.CrossRefPubMed
24.
Soydal Ç, Varlı B, Araz M, Bakırarar B, Taşkın S, Ortaç UF. Radiomics analysis of uterine tumors in 18F-fluorodeoxyglucose positron emission tomography for prediction of lymph node metastases in endometrial carcinoma. Turk J Med Sci. 2022;52:762–9.CrossRefPubMedPubMedCentral
25.
Wang M, Liu L, Dai Q, Jin M, Huang G. Developing a primary tumor and lymph node 18F-FDG PET/CT-clinical (TLPC) model to predict lymph node metastasis of resectable T2–4 NSCLC. J Cancer Res Clin Oncol. 2023;149:247–61.CrossRefPubMed
26.
Taghvaei R, Zadeh MZ, Werner TJ, Alavi A. Critical role of PET/CT-based novel quantitative techniques for assessing global disease activity in multiple myeloma and other hematological malignancies: why it is time to abandon reliance on examining focal lesions. Eur Radiol. 2021;31:149–51.CrossRefPubMed
27.
Wichtmann BD, Harder FN, Weiss K, Schönberg SO, Attenberger UI, Alkadhi H, et al. Influence of image processing on radiomic features from magnetic resonance imaging. Invest Radiol. 2023;58:199–208.CrossRefPubMed
28.
Ponsiglione A, Stanzione A, Spadarella G, Baran A, Cappellini LA, Lipman KG, et al. Ovarian imaging radiomics quality score assessment: an EuSoMII radiomics auditing group initiative. Eur Radiol. 2023;33:2239–47.CrossRefPubMed
29.
Zwanenburg A, Vallières M, Abdalah MA, Aerts HJWL, Andrearczyk V, Apte A, et al. The image biomarker standardization initiative: standardized quantitative radiomics for high-throughput image-based phenotyping. Radiology. 2020;295:328–38.CrossRefPubMed
30.
AkinciD’Antonoli T, Cuocolo R, Baessler B, Pinto Dos Santos D. Towards reproducible radiomics research: introduction of a database for radiomics studies. Eur Radiol. 2024;34:436–43.CrossRef
31.
Mendes Serrão E, Klug M, Moloney BM, Jhaveri A, Lo Gullo R, Pinker K, et al. Current status of cancer genomics and imaging phenotypes: what radiologists need to know. Radiol Imaging Cancer. 2023;5: e220153.CrossRefPubMedPubMedCentral
32.
Steiger P. Radiomics and artificial intelligence: from academia to clinical practice. Radiology. 2022;303:542–3.CrossRefPubMed
Metadaten
Titel
More than meets the eye: 2-[18F]FDG PET-based radiomics predicts lymph node metastasis in colorectal cancer patients to enable precision medicine
verfasst von
Wenpeng Huang
Mai Hong Son
Le Ngoc Ha
Lei Kang
Weibo Cai
Publikationsdatum
01.03.2024
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 6/2024
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-024-06664-3

Weitere Artikel der Ausgabe 6/2024

European Journal of Nuclear Medicine and Molecular Imaging 6/2024 Zur Ausgabe

Short Communication

Initial results with [18F]FAPI-74 PET/CT in idiopathic pulmonary fibrosis

Image of the Month

[18F]F-AlF-NOTA-octreotide PET/CT detected the [18F]FDG negative ectopic ACTH tumor in mediastinum

Image of the Month

False-positive [18F]FAPI-74 uptake caused by blood retention due to external jugular vein thrombus: Pitfall in the early-phase scan

Original Article

First-in-human validation of enzymolysis clearance strategy for decreasing renal radioactivity using modified [68Ga]Ga-HER2 Affibody

Short Communication

[68 Ga]Ga-FAPI-46 PET/CT for locoregional lymph node staging in urothelial carcinoma of the bladder prior to cystectomy: initial experiences from a pilot analysis

Original Article

The accuracy and intra- and interobserver variability of PSMA PET/CT for the local staging of primary prostate cancer