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Head and Neck Pathology

Erschienen in:

16.03.2023 | Special Issue: Top Ten Head and Neck Differentials

Top 10 Clear Cell Head and Neck Lesions to Contemplate

verfasst von: Nicole A. Cipriani, Aanchal Kakkar

Erschienen in: Head and Neck Pathology | Ausgabe 1/2023

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Abstract

Background

Optically clear cytoplasm may occur in neoplastic and non-neoplastic conditions, either as a characteristic feature of a disease entity or as a morphologic rarity, potentially creating diagnostic dilemmas in various organ systems. In the head and neck, clear cell change can occur in lesions of salivary, odontogenic, thyroid, parathyroid, or sinonasal/skull base origin, as well as in metastases to these regions.

Methods

This review elaborates the top ten clear cell lesions in the head and neck, emphasizing their distinguishing histologic, immunohistochemical, and molecular attributes, and presents a rational approach to arriving at an accurate classification.

Results

Cytoplasmic pallor or clearing may be caused by accumulations of glycogen, lipid, mucin, mucopolysaccharides, water, foreign material, hydropic organelles, or immature zymogen granules. Overlapping morphologic features may present a diagnostic challenge to the surgical pathologist. Similarity in immunohistochemical profiles, often due to common cell type, as well as rare non-neoplastic mimics, furthers the diagnostic conundrum.

Conclusions

The top ten lesions reviewed in this article are as follows: (1) clear cell carcinoma (salivary and odontogenic), (2) mucoepidermoid carcinoma, (3) myoepithelial and epithelial-myoepithelial carcinoma, (4) oncocytic salivary gland lesions, (5) squamous cell carcinoma, (6) parathyroid water clear cell adenoma, (7) metastatic renal cell carcinoma (especially in comparison to clear cell thyroid neoplasms), (8) sinonasal renal cell-like adenocarcinoma, (9) chordoma, and (10) rhinoscleroma.

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Titel: Top 10 Clear Cell Head and Neck Lesions to Contemplate
verfasst von: Nicole A. Cipriani
Aanchal Kakkar
Publikationsdatum: 16.03.2023
Verlag: Springer US
Erschienen in: Head and Neck Pathology / Ausgabe 1/2023
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-022-01518-6

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Top 10 Clear Cell Head and Neck Lesions to Contemplate

Abstract

Background

Methods

Results

Conclusions

Neu im Fachgebiet Pathologie

Assistierter Suizid durch Infusion von Thiopental

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Background

Methods

Results

Conclusions

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