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03.04.2024 | Review Article

Tooth whitening: current status and prospects

verfasst von: Kaiyi Li, Shuang Chen, Jingjing Wang, Xuan Xiao, Zhifeng Song, Shangfeng Liu

Erschienen in: Odontology

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Abstract

As a safe, effective, economical, and convenient technique, tooth whitening is one of the most popular treatments for improving tooth discoloration. This review summarizes the theoretical and recent research developments in the classification and mechanisms of tooth discoloration, as well as the principles, agents, effects, and side effects of tooth whitening techniques. The aim is to provide a basis for the clinical treatment of tooth whitening techniques and to suggest possible new ideas for further research. The accepted mechanism of whitening is the redox reaction of oxides in the whitening reagent, and the whitening effect is remarkable. However, side effects such as tooth sensitivity and irritation of gum and other oral soft tissues can still occur. It is recommended that more monitoring be carried out in the clinic to monitor these side effects, and care should be taken to protect the soft tissues in the mouth during office whitening procedures. Furthermore, there is a need to develop new additives or natural whitening products to reduce the occurrence of side effects.

Bahadır HS, Karadağ G, Bayraktar Y. Minimally invasive approach for improving anterior dental aesthetics: case report with 1-year follow-up. Case Rep Dent. 2018;2018:4601795.PubMedPubMedCentral

Bartlett D. Bleaching discoloured teeth. Dent Update. 2001;28:14–8.PubMedCrossRef

Westlake A. Bleaching teeth by electricity. Am J Dent Sci. 1895;29:101–2.PubMedPubMedCentral

Ames WJ. Removing stains from mottled enamel. J Am Dent Assoc Dent Cosmos. 1937;24:1674–7.CrossRef

Bailey RW, Christen AG. Bleaching of vital teeth stained with endemic dental fluorsis. Oral Surg Oral Med Oral Pathol. 1968;26:871–8.PubMedCrossRef

Li Y. Biological properties of peroxide-containing tooth whiteners. Food Chem Toxicol. 1996;34:887–904.PubMedCrossRef

Haywood VB, Heymann HO. Nightguard vital bleaching. Quintessence Int. 1989;20:173–6.PubMed

Joiner A, Luo W. Tooth colour and whiteness: a review. J Dent. 2017;67:S3-10.CrossRef

Kwon SR, Wertz PW. Review of the mechanism of tooth whitening. J Esthet Restor Dent. 2015;27:240–57.PubMedCrossRef

10.

Lindh L, Aroonsang W, Sotres J, Arnebrant T. Salivary pellicles. Monogr Oral Sci. 2014;24:30–9.PubMedCrossRef

11.

Vogel RI. Intrinsic and extrinsic discoloration of the dentition (a literature review). J Oral Med. 1975;30:99–104.PubMed

12.

Nathoo SA. The chemistry and mechanisms of extrinsic and intrinsic discoloration. J Am Dent Assoc. 1997;128:6–10.CrossRef

13.

Sulieman MA. An overview of tooth-bleaching techniques: chemistry, safety and efficacy. Periodontol. 2000;2008(48):148–69.

14.

Jha SK, Mishra VK, Sharma DK, Damodaran T. Fluoride in the environment and its metabolism in humans. Rev Environ Contam Toxicol. 2011;211:121–42.PubMed

15.

Bharath KP, Subba Reddy VV, Poornima P, Revathy V, Kambalimath HV, Karthik B. Comparison of relative efficacy of two techniques of enamel stain removal on fluorosed teeth. An in vivo study. J Clin Pediatr Dent. 2014;38:207–13.PubMedCrossRef

16.

Sulieman M, Addy M, Macdonald E, Rees JS. The bleaching depth of a 35% hydrogen peroxide based in-office product: a study in vitro. J Dent. 2005;33:33–40.PubMedCrossRef

17.

Fasanaro TS. Bleaching teeth: history, chemicals, and methods used for common tooth discolorations. J Esthet Dent. 1992;4:71–8.PubMedCrossRef

18.

Weiger R, Kuhn A, Löst C. In vitro comparison of various types of sodium perborate used for intracoronal bleaching of discolored teeth. J Endod. 1994;20:338–41.PubMedCrossRef

19.

Kihn PW. Vital tooth whitening. Dent Clin N Am. 2007;51:319–31.PubMedCrossRef

20.

Niessen LC. Tooth whitening: why, who, where, what, and how. J Esthet Restor Dent. 2001;13:79–80.PubMedCrossRef

21.

Attin T, Paqué F, Ajam F, Lennon AM. Review of the current status of tooth whitening with the walking bleach technique. Int Endod J. 2003;36:313–29.PubMedCrossRef

22.

Shi XC, Ma H, Zhou JL, Li W. The effect of cold-light-activated bleaching treatment on enamel surfaces in vitro. Int J Oral Sci. 2012;4:208–13.PubMedPubMedCentralCrossRef

23.

Haywood VB, Sword RJ. Tray bleaching status and insights. J Esthet Restor Dent. 2021;33:27–38.PubMedCrossRef

24.

Mokhlis GR, Matis BA, Cochran MA, Eckert GJ. A clinical evaluation of carbamide peroxide and hydrogen peroxide whitening agents during daytime use. J Am Dent Assoc. 2000;131:1269–77.PubMedCrossRef

25.

Maran BM, Vochikovski L, de Andrade Hortkoff DR, Stanislawczuk R, Loguercio AD, Reis A. Tooth sensitivity with a desensitizing-containing at-home bleaching gel—a randomized triple-blind clinical trial. J Dent. 2018;72:64–70.PubMedCrossRef

26.

Carey CM. Tooth whitening: what we now know. J Evid Based Dent Pract. 2014;14:70–6.PubMedCrossRef

27.

Collins LZ, Naeeni M, Platten SM. Instant tooth whitening from a silicatoothpaste containing blue covarine. J Dent. 2008;36:S21–5.PubMedCrossRef

28.

Dantas AA, Bortollatto JF, Roncolato A, Merchan H, Floros MC, Kuga MC, et al. Can a bleaching toothpaste containing blue covarine demonstrate the same bleaching as conventional techniques? An in vitro, randomized and blinded study. J Appl Oral Sci. 2015;23:609–13.PubMedPubMedCentralCrossRef

29.

Yudhira R, Peumans M, Barker ML, Gerlach RW. Clinical trial of tooth whitening with 6% hydrogen peroxide whitening strips and two whitening dentifrices. Am J Dent. 2007;20:32A-36A.PubMed

30.

Demarco FF, Meireles SS, Masotti AS. Over-the-counter whitening agents: a concise review. Braz Oral Res. 2009;23:64–70.PubMedCrossRef

31.

Oliveira GM, Miguez PA, Oliveira GB, Swift EJ Jr, Farrell S, Anastasia MK, et al. Safety and efficacy of a high-adhesion whitening strip under extended wear regimen. J Dent. 2013;1:e46–52.CrossRef

32.

Swift EJ Jr, Heymann HO, Wilder AD Jr, Barker ML, Gerlach RW. Effects of duration of whitening strip treatment on tooth color: a randomized, placebo-controlled clinical trial. J Dent. 2009;37:e51–6.PubMedCrossRef

33.

Collins LZ, Maggio B, Liebman J, Blanck M, Lefort S, Waterfield P, et al. Clinical evaluation of a novel whitening gel, containing 6% hydrogen peroxide and a standard fluoride toothpaste. J Dent. 2004;32:13–7.PubMedCrossRef

34.

Plotino G, Buono L, Grande NM, Pameijer CH, Somma F. Nonvital tooth bleaching: a review of the literature and clinical procedures. J Endod. 2008;34:394–407.PubMedCrossRef

35.

Lindén LA. Microscopic observations of fluid flow through enamel in vitro. Odontol Revy. 1968;19:349–65.PubMed

36.

Kalia YN, Guy RH. Modeling transdermal drug release. Adv Drug Deliv Rev. 2001;48:159–72.PubMedCrossRef

37.

Aschheim KW. Bleaching and related agents-ScienceDirect. Esthet Dent (Third Edition). 2015;23:252–80.

38.

Farawati FAL, Hsu SM, O’Neill E, Neal D, Clark A, Esquivel-Upshaw J. Effect of carbamide peroxide bleaching on enamel characteristics and susceptibility to further discoloration. J Prosthet Dent. 2019;121:340–6.PubMedCrossRef

39.

Wang W, Zhu Y, Li J, Liao S, Ai H. Efficacy of cold light bleaching using different bleaching times and their effects on human enamel. Dent Mater J. 2013;32:761–6.PubMedCrossRef

40.

Cheng HJ, Geng Y, Zhao J. Evaluation of the effectiveness of cold-light whitening technique on tetracycline pigmentation teeth and aged extrinsic stain teeth. Shanghai Kou Qiang Yi Xue. 2018;27:65–7.PubMed

41.

Palo RM, Valera MC, Camargo SE, Camargo CH, Cardoso PE, Mancini MN, et al. Peroxide penetration from the pulp chamber to the external root surface after internal bleaching. Am J Dent. 2010;23:171–4.PubMed

42.

Hanks CT, Fat JC, Wataha JC, Corcoran JF. Cytotoxicity and dentin permeability of carbamide peroxide and hydrogen peroxide vital bleaching materials, in vitro. J Dent Res. 1993;72:931–8.PubMedCrossRef

43.

Camps J, de Franceschi H, Idir F, Roland C. About I: time-course diffusion of hydrogen peroxide through human dentin: clinical significance for young tooth internal bleaching. J Endod. 2007;33:455–9.PubMedCrossRef

44.

Camargo SE, Valera MC, Camargo CH, Gasparoto Mancini MN, Menezes MM. Penetration of 38% hydrogen peroxide into the pulp chamber in bovine and human teeth submitted to office bleach technique. J Endod. 2007;33:1074–7.PubMedCrossRef

45.

Palo RM, Bonetti-Filho I, Valera MC, Camargo CH, Camargo S, Moura-Netto C, et al. Quantification of peroxide ion passage in dentin, enamel, and cementum after internal bleaching with hydrogen peroxide. Oper Dent. 2012;37:660–4.PubMedCrossRef

46.

Camargo SE, Cardoso PE, Valera MC, de Araújo MA, Kojima AN. Penetration of 35% hydrogen peroxide into the pulp chamber in bovine teeth after LED or Nd:YAG laser activation. Eur J Esthet Dent. 2009;4:82–8.PubMed

47.

Drew CP. Teeth bleaching a vital technique for you to know. Dent Assist (Waco Tx). 1988;8:23–5.PubMed

48.

Seghi RR, Denry I. Effects of external bleaching on indentation and abrasion characteristics of human enamel in vitro. J Dent Res. 1992;71:1340–4.PubMedCrossRef

49.

Pontes M, Gomes J, Lemos C, Leão RS, Moraes S, Vasconcelos B, et al. Effect of bleaching gel concentration on tooth color and sensitivity: a systematic review and meta-analysis. Oper Dent. 2020;45:265–75.PubMedCrossRef

50.

Chemin K, Rezende M, Milan FM, Dantas TB, Gomes KDN, Kossatz S. Clinical evaluation of 10% hydrogen peroxide on tooth sensitivity and effectiveness in at home dental bleaching. J Contemp Dent Pract. 2018;19:1376–80.PubMedCrossRef

51.

Pereira R, Silveira J, Dias S, Cardoso A, Mata A, Marques D. Bleaching efficacy and quality of life of different bleaching techniques—randomized controlled trial. Clin Oral Investig. 2022;34:1–11.

52.

Haywood VB. Frequently asked questions about bleaching. Compend Contin Educ Dent. 2003;24:324–38.PubMed

53.

Matis BA. Degradation of gel in tray whitening. Compend Contin Educ Dent Suppl. 2000;28:25–31.

54.

Furlan IS, Bridi EC, Amaral F, França FMG, Turssi CP, Basting RT. Effect of high- or low-concentration bleaching agents containing calcium and/or fluoride on enamel microhardness. Gen Dent. 2017;65:66–70.PubMed

55.

Ari H, Ungör M. In vitro comparison of different types of sodium perborate used for intracoronal bleaching of discoloured teeth. Int Endod J. 2002;35:433–6.PubMedCrossRef

56.

Rotstein I, Mor C, Friedman S. Prognosis of intracoronal bleaching with sodium perborate preparation in vitro: 1-year study. J Endod. 1993;19:10–2.PubMedCrossRef

57.

Haywood VB, Sword RJ. Tooth bleaching questions answered. Br Dent J. 2017;223:369–80.PubMedCrossRef

58.

Ablal MA, Adeyemi AA, Jarad FD. The whitening effect of chlorine dioxide—an in vitro study. J Dent. 2013;41:76–81.CrossRef

59.

Olms C, Klinke T, Pirek P, Hannak WB. Randomized multi-centre study on the effect of training on tooth shade matching. J Dent. 2013;41:1259–63.PubMedCrossRef

60.

Chu SJ, Trushkowsky RD, Paravina RD. Dental color matching instruments and systems. Review of clinical and research aspects. J Dent. 2010;38:2–16.CrossRef

61.

Ozdemir ZM, Surmelioglu D. Effects of different bleaching application time on tooth color and mineral alteration. Ann Anat. 2021;233: 151590.PubMedCrossRef

62.

Pini NIP, Piccelli MR, Vieira-Junior WF, Ferraz LN, Aguiar FHB, Lima D. In-office tooth bleaching with chitosan-enriched hydrogen peroxide gels: in vitro results. Clin Oral Investig. 2022;26:471–9.PubMedCrossRef

63.

Yuan K, Sun X, Wang F, Wang H, Chen JH. In vitro and in vivo evaluations of three computer-aided shade matching instruments. Oper Dent. 2012;37:219–27.PubMedCrossRef

64.

Chu SJ. Use of a reflectance spectrophotometer in evaluating shade change resulting from tooth-whitening products. J Esthet Restor Dent. 2003;15:42–8.

65.

Johnston WM. Color measurement in dentistry. J Dent. 2009;37(Suppl 1):e2-6.PubMedCrossRef

66.

Luo W, Westland S, Ellwood R, Pretty I, Cheung V. Development of a whiteness index for dentistry. J Dent. 2009;37(Suppl 1):e21-26.PubMedCrossRef

67.

Sulieman M. An overview of bleaching techniques: I. History, chemistry, safety and legal aspects. Dent Update. 2004;31:608–10.PubMedCrossRef

68.

Maran BM, Matos TP, de Castro ADS, Vochikovski L, Amadori AL, Loguercio AD, et al. In-office bleaching with low/medium vs. high concentrate hydrogen peroxide: a systematic review and meta-analysis. J Dent. 2020;103:103–9.CrossRef

69.

Maran BM, Burey A, de Paris MT, Loguercio AD, Reis A. In-office dental bleaching with light vs. without light: a systematic review and meta-analysis. J Dent. 2018;70:1–13.PubMedCrossRef

70.

Polydorou O, Wirsching M, Wokewitz M, Hahn P. Three-month evaluation of vital tooth bleaching using light units—a randomized clinical study. Oper Dent. 2013;38:21–32.PubMedCrossRef

71.

Miranda CB, Pagani C, Benetti AR, Matuda FS. Evaluation of the bleached human enamel by scanning electron microscopy. J Appl Oral Sci. 2005;13:204–11.PubMedCrossRef

72.

Bitter NC. A scanning electron microscopy study of the effect of bleaching agents on enamel: a preliminary report. J Prosthet Dent. 1992;67:852–5.PubMedCrossRef

73.

Mondelli RFL, Gabriel T, Rizzante FAP, Magalhães AC, Bombonatti JFS, Ishikiriama SK. Do different bleaching protocols affect the enamel microhardness? Eur J Dent. 2015;9:25–30.PubMedCrossRef

74.

Elfallah HM, Swain MV. A review of the effect of vital teeth bleaching on the mechanical properties of tooth enamel. N Z Dent J. 2013;109:87–96.PubMed

75.

Jiang T, Ma X, Wang Y, Tong H, Shen X, Hu Y, et al. Investigation of the effects of 30% hydrogen peroxide on human tooth enamel by Raman scattering and laser-induced fluorescence. J Biomed Opt. 2008;13:14–9.CrossRef

76.

Basting RT, Rodrigues AL Jr, Serra MC. The effects of seven carbamide peroxide bleaching agents on enamel microhardness over time. J Am Dent Assoc. 2003;134:1335–42.PubMedCrossRef

77.

Klarić E, Marcius M, Ristić M, Sever I, Prskalo K, Tarle Z. Surface changes of enamel and dentin after two different bleaching procedures. Acta Clin Croat. 2013;52:419–29.PubMed

78.

Lewinstein I, Fuhrer N, Churaru N, Cardash H. Effect of different peroxide bleaching regimens and subsequent fluoridation on the hardness of human enamel and dentin. J Prosthet Dent. 2004;92:337–42.PubMedCrossRef

79.

Moraes RR, Marimon JL, Schneider LF, Correr Sobrinho L, Camacho GB, Bueno M. Carbamide peroxide bleaching agents: effects on surface roughness of enamel, composite and porcelain. Clin Oral Investig. 2006;10:23–8.PubMedCrossRef

80.

Cadenaro M, Breschi L, Nucci C, Antoniolli F, Visintini E, Prati C, et al. Effect of two in-office whitening agents on the enamel surface in vivo: a morphological and non-contact profilometric study. Oper Dent. 2008;33:127–34.PubMedCrossRef

81.

Sun L, Liang S, Sa Y, Wang Z, Ma X, Jiang T, et al. Surface alteration of human tooth enamel subjected to acidic and neutral 30% hydrogen peroxide. J Dent. 2011;39:686–92.PubMedCrossRef

82.

Trentino AC, Soares AF, Duarte MA, Ishikiriama SK, Mondelli RF. Evaluation of pH levels and surface roughness after bleaching and abrasion tests of eight commercial products. Photomed Laser Surg. 2015;33:372–7.PubMedCrossRef

83.

Grobler SR, Majeed A, Moola MH. Effect of various tooth-whitening products on enamel microhardness. Sadj. 2009;64:474–9.PubMed

84.

Jorgensen MG, Carroll WB. Incidence of tooth sensitivity after home whitening treatment. J Am Dent Assoc. 2002;133:1076–82.PubMedCrossRef

85.

Sato C, Rodrigues FA, Garcia DM, Vidal CM, Pashley DH, Tjäderhane L, et al. Tooth bleaching increases dentinal protease activity. J Dent Res. 2013;92:187–92.PubMedCrossRef

86.

Majeed A, Farooq I, Grobler SR, Rossouw RJ. Tooth-bleaching: a review of the efficacy and adverse effects of various tooth whitening products. J Coll Physicians Surg Pak. 2015;25:891–6.PubMed

87.

Rezende M, Coppla FM, Chemin K, Chibinski AC, Loguercio AD, Reis A. Tooth sensitivity after dental bleaching with a desensitizer-containing and a desensitizer-free bleaching gel: a systematic review and meta-analysis. Oper Dent. 2019;44:58–74.CrossRef

88.

Pretty IA, Ellwood RP, Brunton PA, Aminian A. Vital tooth bleaching in dental practice: 1. Professional bleaching. Dent Update. 2006;33:288–90.PubMedCrossRef

89.

Munro IC, Williams GM, Heymann HO, Kroes R. Tooth whitening products and the risk of oral cancer. Food Chem Toxicol. 2006;44:301–15.PubMedCrossRef

90.

Haywood VB, Caughman WF, Frazier KB, Myers ML. Tray delivery of potassium nitrate-fluoride to reduce bleaching sensitivity. Quintessence Int. 2001;32:105–9.PubMed

91.

Carrouel F, Viennot S, Ottolenghi L, Gaillard C, Bourgeois D. Nanoparticles as anti-microbial, anti-inflammatory, and remineralizing agents in oral care cosmetics: a review of the current situation. Nanomaterials. 2020;10(1):140.PubMedPubMedCentralCrossRef

92.

Hammad SM, El-Wassefy NA, Alsayed MA. Evaluation of color changes of white spot lesions treated with three different treatment approaches: an in-vitro study. Dental Press J Orthod. 2020;25(1):26–7.PubMedPubMedCentralCrossRef

93.

Orilisi G, Tosco V, Monterubbianesi R, Notarstefano V, Özcan M, Putignano A, Orsini G. ATR-FTIR, EDS and SEM evaluations of enamel structure after treatment with hydrogen peroxide bleaching agents loaded with nano-hydroxyapatite particles. PeerJ. 2021;9:e10606.PubMedPubMedCentralCrossRef

94.

Juntavee A, Juntavee N, Sinagpulo AN. Nano-hydroxyapatite gel and its effects on remineralization of artificial carious lesions. Int J Dent. 2021;2021:7256056.PubMedPubMedCentralCrossRef

95.

Philip N. State of the art enamel remineralization systems: the next frontier in caries management. Caries Res. 2019;53(3):284–95.PubMedCrossRef

96.

Memarpour M, Shafiei F, Rafiee A, Soltani M, Dashti MH. Effect of hydroxyapatite nanoparticles on enamel remineralization and estimation of fissure sealant bond strength to remineralized tooth surfaces: an in vitro study. BMC Oral Health. 2019;19(1):92.PubMedPubMedCentralCrossRef

97.

Gomes YSL, Alexandrino LD, Alencar CM, Alves EB, Faial KC, Silva CM. In situ effect of nanohydroxyapatite paste in enamel teeth bleaching. J Contemp Dent Pract. 2017;18(11):996–1003.PubMedCrossRef

98.

Monterubbianesi R, Tosco V, Bellezze T, Giuliani G, Özcan M, Putignano A, Orsini G. A comparative evaluation of nanohydroxyapatite-enriched hydrogen peroxide home bleaching system on color, hardness and microstructure of dental enamel. Materials (Basel). 2021;14(11):3072.PubMedCrossRef

99.

Reynolds EC. Remineralization of enamel subsurface lesions by casein phosphopeptide-stabilized calcium phosphate solutions. J Dent Res. 1997;76:1587–95.PubMedCrossRef

100.

Iijima Y, Cai F, Shen P, Walker G, Reynolds C, Reynolds EC. Acid resistance of enamel subsurface lesions remineralized by a sugar-free chewing gum containing casein phosphopeptide- amorphous calcium phosphate. Caries Res. 2004;38:551–6.PubMedCrossRef

101.

Rahiotis C, Vougiouklakis G. Effect of a CPP-ACP agent on the demineralization and remineralization of dentine in vitro. J Dent. 2007;35:695–8.PubMedCrossRef

102.

Manton EJ, Bhide R, Hopcraft MS, Reynolds EC. Effect of ozone and tooth mousse on the efficacy of peroxide bleaching. Aust Dent J. 2008;53:128–32.PubMedCrossRef

103.

Jacob SE, Varghese JO, Singh S, Natarajan S, Thomas MS. Effect of bleaching on color and surface topography of teeth with enamel caries treated with resin infiltration (ICON®) and remineralization (casein phosphopeptide-amorphous calcium phosphate). J Conserv Dent. 2023;26(4):377–82.

104.

Llena C, Esteve I, Rodríguez-Lozano FJ, Forner L. The application of casein phosphopeptide and amorphous calcium phosphate with fluoride (CPP-ACPF) for restoring mineral loss after dental bleaching with hydrogen or carbamide peroxide: an in vitro study. Ann Anat. 2019;225:48–53.PubMedCrossRef

105.

Zhu H, Zheng J, Oh XY, Chan CY, Low BQL, Tor JQ, Jiang W, Ye E, Loh XJ, Li Z. Nanoarchitecture-integrated hydrogel systems toward therapeutic applications. ACS Nano. 2023;17(9):7953–78.PubMedCrossRef

106.

Huang M, Huang Y, Liu H, Tang Z, Chen Y, Huang Z, Xu S, Du J, Jia B. Hydrogels for the treatment of oral and maxillofacial diseases: current research, challenges, and future directions. Biomater Sci. 2022;10(22):6413–46.PubMedCrossRef

Titel: Tooth whitening: current status and prospects
verfasst von: Kaiyi Li
Shuang Chen
Jingjing Wang
Xuan Xiao
Zhifeng Song
Shangfeng Liu
Publikationsdatum: 03.04.2024
Verlag: Springer Nature Singapore
Erschienen in: Odontology
Print ISSN: 1618-1247
Elektronische ISSN: 1618-1255
DOI: https://doi.org/10.1007/s10266-024-00914-4

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