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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

18.12.2023 | Short Communication

Quantitative analysis of myocardial blood flow in surgically revascularized and not revascularized myocardial segments. A pilot PET study

verfasst von: M. Grandinetti, G. Locorotondo, L. Leccisotti, A. Guarneri, P. Bruno, A. Marcolini, P. Farina, M. F. Gaudino, G. A. Lanza, F. Crea, A. Giordano, M. Massetti

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 6/2024

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Abstract

Purpose

To prospectively compare changes in myocardial blood flow (MBF) and myocardial flow reserve (MFR) in multivessel coronary artery disease (MVCAD) patients undergoing incomplete revascularization (IR) versus complete revascularization (CR) by coronary artery bypass grafting (CABG).

Methods

Seven male patients (age 68 ± 9 years) with MVCAD underwent myocardial perfusion PET/CT with [13N]ammonia before and at least 4 months after CABG. Segmental resting and stress MBF as well as MFR were measured. Resting and during stress left ventricle ejection fraction (LVEF) were also calculated.

Results

Three patients (43%) underwent CR and four (57%) IR. Among 119 myocardial segments, 101 (85%) were revascularized, and 18 (15%) were not. After CABG, stress MBF (mL/min/gr) and MFR are significantly increased in all myocardial segments, with a greater increase in the revascularized segments (p = 0.013). In both groups, LVEF significantly decreased during stress at baseline PET (p = 0.04), but not after CABG.

Conclusion

Stress MBF and MFR significantly improve after CABG in both revascularized and not directly revascularized myocardial segments. IR strategy may be considered in patients with high surgical risk for CR.

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Titel: Quantitative analysis of myocardial blood flow in surgically revascularized and not revascularized myocardial segments. A pilot PET study
verfasst von: M. Grandinetti
G. Locorotondo
L. Leccisotti
A. Guarneri
P. Bruno
A. Marcolini
P. Farina
M. F. Gaudino
G. A. Lanza
F. Crea
A. Giordano
M. Massetti
Publikationsdatum: 18.12.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 6/2024
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-023-06563-z

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Quantitative analysis of myocardial blood flow in surgically revascularized and not revascularized myocardial segments. A pilot PET study

Abstract

Purpose

Methods

Results

Conclusion

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Abstract

Purpose

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