Skip to main content
Erschienen in: Current Pain and Headache Reports 11/2023

25.09.2023 | Uncommon and/or Unusual Headaches and Syndromes (F Cohen, Section Editor)

Primary Cough Headache

verfasst von: Arathi Nandyala, Niushen Zhang

Erschienen in: Current Pain and Headache Reports | Ausgabe 11/2023

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

In this review article, we summarize the most recent findings and observations in patients experiencing primary cough headache.

Recent Findings

Recent studies draw attention to further characterization of patients with primary cough headache in a pulmonology clinic. There have also been recent case studies describing new therapy considerations, including noninvasive vagus nerve stimulation and lumbar punctures.

Summary

Primary cough headache has been a recognized entity since as early as 1932. Patients generally report a sudden onset, sharp headache lasting a few hours that is precipitated by Valsalva maneuver or coughing. It remains an uncommon diagnosis, and secondary causes are crucial to rule out with imaging studies. Additionally, there can be an overlap with other primary headache disorders such as primary exercise headache and headache associated with sexual activity, thus requiring a detailed history. Many hypotheses exist regarding the pathophysiology including relative pressure gradients and a crowded posterior fossa. Generally, patients are responsive to indomethacin, but more recent case reports have suggested benefits of other medications and procedures that may offer patients an alternative option, including vagus nerve stimulation, lumbar punctures, and beta blockers. Future case series and studies should focus on management of these patients, with a specific focus on individuals who do not tolerate indomethacin.
Literatur
1.
Zurück zum Zitat Tinel J. La céphalée a l’effort. Syndrome de distension douloureuse des veines intracraniennes. Medicine (Paris). 1932;13:113–8. Tinel J. La céphalée a l’effort. Syndrome de distension douloureuse des veines intracraniennes. Medicine (Paris). 1932;13:113–8.
3.
Zurück zum Zitat Souza WP, Sousa‐Santos PM, Silva‐Néto RP. A historical review of headaches: who first described them and when did this occur? Headache. 2020;60(8):1535–41. Souza WP, Sousa‐Santos PM, Silva‐Néto RP. A historical review of headaches: who first described them and when did this occur? Headache. 2020;60(8):1535–41.
5.
Zurück zum Zitat Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018; 38(1): 1- 211: Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018; 38(1): 1- 211:
6.
Zurück zum Zitat Pascual J, Combarros O, Leno C, Polo JM, Rebollo Alvarez-Armandi M, Berciano J. Distribución por diagnósticos del dolor de cabeza como motivo de consulta neurológica. Med Clin. 1995;104(5):161–4. Pascual J, Combarros O, Leno C, Polo JM, Rebollo Alvarez-Armandi M, Berciano J. Distribución por diagnósticos del dolor de cabeza como motivo de consulta neurológica. Med Clin. 1995;104(5):161–4.
7.
Zurück zum Zitat Rasmussen BK, Olesen J. Symptomatic and nonsymptomatic headaches in a general population. Neurology. 1992;42(6):1225. Rasmussen BK, Olesen J. Symptomatic and nonsymptomatic headaches in a general population. Neurology. 1992;42(6):1225.
8.
Zurück zum Zitat Chen PK, Fuh JL, Wang SJ. Cough headache: a study of 83 consecutive patients. Cephalalgia. 2009;29(10):1079–85.CrossRefPubMed Chen PK, Fuh JL, Wang SJ. Cough headache: a study of 83 consecutive patients. Cephalalgia. 2009;29(10):1079–85.CrossRefPubMed
9.
Zurück zum Zitat Pascual J, Iglesias F, Oterino A, Vazquez-Barquero A, Berciano J. Cough, exertional, and sexual headaches: an analysis of 72 benign and symptomatic cases. Neurology. 1996;46(6):1520–4.CrossRefPubMed Pascual J, Iglesias F, Oterino A, Vazquez-Barquero A, Berciano J. Cough, exertional, and sexual headaches: an analysis of 72 benign and symptomatic cases. Neurology. 1996;46(6):1520–4.CrossRefPubMed
10.
Zurück zum Zitat Alvarez R, Ramón C, Pascual J. Clues in the differential diagnosis of primary vs secondary cough, exercise, and sexual headaches. Headache: J Head Face Pain. 2014;54(9):1560–2. Alvarez R, Ramón C, Pascual J. Clues in the differential diagnosis of primary vs secondary cough, exercise, and sexual headaches. Headache: J Head Face Pain. 2014;54(9):1560–2.
11.
Zurück zum Zitat Villar‐Martínez MD, Moreno‐Ajona D, Chan C, Goadsby PJ. Indomethacin‐responsive headaches—a narrative review. Headache: J Head Face Pain. 2021;61(5):700–14. Villar‐Martínez MD, Moreno‐Ajona D, Chan C, Goadsby PJ. Indomethacin‐responsive headaches—a narrative review. Headache: J Head Face Pain. 2021;61(5):700–14.
12.
Zurück zum Zitat •• Zhang Y, Zhao X, Wang Y, Dong Z, Yu S. Prevalence and characteristics of cough headache in a Chinese respiratory clinic. Cephalalgia. 2021;41(3):366–74. A clinical study evaluating the demographics and clinical features of patients with primary cough headache in a respiratory clinic. •• Zhang Y, Zhao X, Wang Y, Dong Z, Yu S. Prevalence and characteristics of cough headache in a Chinese respiratory clinic. Cephalalgia. 2021;41(3):366–74. A clinical study evaluating the demographics and clinical features of patients with primary cough headache in a respiratory clinic.
13.
Zurück zum Zitat Raskin NH. The cough headache syndrome: treatment. Neurology. 1995;45(9):1784-. Raskin NH. The cough headache syndrome: treatment. Neurology. 1995;45(9):1784-.
14.
Zurück zum Zitat Donnet A, Valade D, Houdart E, Lanteri-Minet M, Raffaelli C, Demarquay G, et al. Primary cough headache, primary exertional headache, and primary headache associated with sexual activity: a clinical and radiological study. Neuroradiology. 2013;55:297–305.CrossRefPubMed Donnet A, Valade D, Houdart E, Lanteri-Minet M, Raffaelli C, Demarquay G, et al. Primary cough headache, primary exertional headache, and primary headache associated with sexual activity: a clinical and radiological study. Neuroradiology. 2013;55:297–305.CrossRefPubMed
16.
Zurück zum Zitat Chen YY, Lirng JF, Fuh JL, Chang FC, Cheng HC, Wang SJ. Primary cough headache is associated with posterior fossa crowdedness: a morphometric MRI study. Cephalalgia. 2004;24(9):694–9.CrossRefPubMed Chen YY, Lirng JF, Fuh JL, Chang FC, Cheng HC, Wang SJ. Primary cough headache is associated with posterior fossa crowdedness: a morphometric MRI study. Cephalalgia. 2004;24(9):694–9.CrossRefPubMed
17.
Zurück zum Zitat Wang SJ, Fuh JL, Lu SR. Benign cough headache is responsive to acetazolamide. Neurology. 2000;55(1):149–50.CrossRefPubMed Wang SJ, Fuh JL, Lu SR. Benign cough headache is responsive to acetazolamide. Neurology. 2000;55(1):149–50.CrossRefPubMed
18.
Zurück zum Zitat Wolff HG. Pain-sensitive structures within the cranial cavity. Headache and other pain, 2nd edn. Oxford university Press, New York. 1963:53–95. Wolff HG. Pain-sensitive structures within the cranial cavity. Headache and other pain, 2nd edn. Oxford university Press, New York. 1963:53–95.
19.
Zurück zum Zitat Rissardo JP, Caprara AL. Cough, cough-induced, and primary cough headache. Matrix Science Medica. 2022;6(4):117–8.CrossRef Rissardo JP, Caprara AL. Cough, cough-induced, and primary cough headache. Matrix Science Medica. 2022;6(4):117–8.CrossRef
21.
Zurück zum Zitat Pavão Martins I, Viana P. “Cough hemicrania”–an overlapping form of headache. Headache. 2017;57(5):796–800. Pavão Martins I, Viana P. “Cough hemicrania”–an overlapping form of headache. Headache. 2017;57(5):796–800.
22.
Zurück zum Zitat Thunstedt DC, Schmutzer M, Fabritius MP, Thorsteinsdottir J, Kunz M, Ruscheweyh R, et al. Headache characteristics and postoperative course in Chiari I malformation. Cephalalgia. 2022;42(9):879–87.CrossRefPubMedPubMedCentral Thunstedt DC, Schmutzer M, Fabritius MP, Thorsteinsdottir J, Kunz M, Ruscheweyh R, et al. Headache characteristics and postoperative course in Chiari I malformation. Cephalalgia. 2022;42(9):879–87.CrossRefPubMedPubMedCentral
23.
Zurück zum Zitat Skau M, et al. What is new about idiopathic intracranial hypertension? An updated review of mechanism and treatment. Cephalalgia. 2006;26(4):384–99.CrossRefPubMed Skau M, et al. What is new about idiopathic intracranial hypertension? An updated review of mechanism and treatment. Cephalalgia. 2006;26(4):384–99.CrossRefPubMed
24.
Zurück zum Zitat Evans RW, Boes CJ. Spontaneous low cerebrospinal fluid pressure syndrome can mimic primary cough headache. Headache. 2005;45(4):374–7. Evans RW, Boes CJ. Spontaneous low cerebrospinal fluid pressure syndrome can mimic primary cough headache. Headache. 2005;45(4):374–7.
25.
Zurück zum Zitat Heijkoop TY, Hammer S, Koppen H. Cough headache in a patient with an intradiploic leptomeningeal cyst: a case report. Headache. 2019;59(4):590–2. Heijkoop TY, Hammer S, Koppen H. Cough headache in a patient with an intradiploic leptomeningeal cyst: a case report. Headache. 2019;59(4):590–2.
26.
Zurück zum Zitat Cordenier A, De Hertogh W, De Keyser J, Versijpt J. Headache associated with cough: a review. J Headache Pain. 2013;14(1):1–7.CrossRef Cordenier A, De Hertogh W, De Keyser J, Versijpt J. Headache associated with cough: a review. J Headache Pain. 2013;14(1):1–7.CrossRef
27.
Zurück zum Zitat Haddad T, Wang V, Parikh S. Cerebral venous sinus pressure and head pain: a case of cough headache secondary to superior sagittal sinus stenosis (P3–12.009). Haddad T, Wang V, Parikh S. Cerebral venous sinus pressure and head pain: a case of cough headache secondary to superior sagittal sinus stenosis (P3–12.009).
28.
Zurück zum Zitat Maramattom BV. Cough headache as a presenting feature of posterior reversible encephalopathy syndrome (PRES). Clin Med. 2021;21(2):e237. Maramattom BV. Cough headache as a presenting feature of posterior reversible encephalopathy syndrome (PRES). Clin Med. 2021;21(2):e237.
29.
Zurück zum Zitat Sandoe CH, Kingston W. Exercise headache: a review. Curr Neurol Neurosci Rep. 2018;18:1–6.CrossRef Sandoe CH, Kingston W. Exercise headache: a review. Curr Neurol Neurosci Rep. 2018;18:1–6.CrossRef
30.
Zurück zum Zitat Mathew NT. Indomethacin responsive headache syndromes. Headache. 1981;21(4):147–50. Mathew NT. Indomethacin responsive headache syndromes. Headache. 1981;21(4):147–50.
31.
Zurück zum Zitat Diamond S, Medina JL. Benign exertional headache-successful treatment with indomethacin. InHeadache 1979 (Vol. 19, No. 4, pp. 249–249). 875 Kings Highway, Ste 200, Woodbury, NJ 08096: Amer Assoc Study Headache. Diamond S, Medina JL. Benign exertional headache-successful treatment with indomethacin. InHeadache 1979 (Vol. 19, No. 4, pp. 249–249). 875 Kings Highway, Ste 200, Woodbury, NJ 08096: Amer Assoc Study Headache.
32.
Zurück zum Zitat •• Moreno-Ajona D, Villar-Martínez MD, Goadsby PJ, Hoffmann J. Primary cough headache treated with non-invasive vagal nerve stimulation. Neurology. 2020;95(13):593–4. Case study describing the use of non-invasive vagus nerve stimulation for the treatment of primary cough headache. •• Moreno-Ajona D, Villar-Martínez MD, Goadsby PJ, Hoffmann J. Primary cough headache treated with non-invasive vagal nerve stimulation. Neurology. 2020;95(13):593–4. Case study describing the use of non-invasive vagus nerve stimulation for the treatment of primary cough headache.
33.
Zurück zum Zitat Villar-Martinez MD, Goadsby PJ. Non-invasive neuromodulation of the cervical vagus nerve in rare primary headaches. Front Pain Res. 2023;4. Villar-Martinez MD, Goadsby PJ. Non-invasive neuromodulation of the cervical vagus nerve in rare primary headaches. Front Pain Res. 2023;4.
34.
Zurück zum Zitat • Kesserwani H, Kesserwani HN. Primary cough headache disorder responds to low volume therapeutic lumbar puncture: a case report with a side note on therapeutics and cranio-spinal dissociation. Cureus. 2020;12(9). Case study describing the use of low volume lumbar puncture for the treatment of primary cough headache. • Kesserwani H, Kesserwani HN. Primary cough headache disorder responds to low volume therapeutic lumbar puncture: a case report with a side note on therapeutics and cranio-spinal dissociation. Cureus. 2020;12(9). Case study describing the use of low volume lumbar puncture for the treatment of primary cough headache.
35.
Zurück zum Zitat Upadhyaya P, Nandyala A, Ailani J. Primary exercise headache. Curr Neurol Neurosci Rep. 2020;20:1–4.CrossRef Upadhyaya P, Nandyala A, Ailani J. Primary exercise headache. Curr Neurol Neurosci Rep. 2020;20:1–4.CrossRef
36.
Zurück zum Zitat Medrano V, Mallada J, Sempere AP, Fernandez S, Piqueras L. Primary cough headache responsive to topiramate. Cephalalgia. 2005;25(8):627.CrossRefPubMed Medrano V, Mallada J, Sempere AP, Fernandez S, Piqueras L. Primary cough headache responsive to topiramate. Cephalalgia. 2005;25(8):627.CrossRefPubMed
Metadaten
Titel
Primary Cough Headache
verfasst von
Arathi Nandyala
Niushen Zhang
Publikationsdatum
25.09.2023
Verlag
Springer US
Erschienen in
Current Pain and Headache Reports / Ausgabe 11/2023
Print ISSN: 1531-3433
Elektronische ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-023-01171-w

Weitere Artikel der Ausgabe 11/2023

Current Pain and Headache Reports 11/2023 Zur Ausgabe

Neuromodulation (A Abd-Elsayed, Section Editor)

Neuromodulation for the Sphenopalatine Ganglion—a Narrative Review

Secondary Headache (M Robbins, Section Editor)

Spontaneous Intracranial Hypotension in Pregnancy

Hot Topics in Pain and Headache (N Rosen, Section Editor)

Does Tension Headache Have a Central or Peripheral Origin? Current State of Affairs

Regenerative Pain Medicine/Interventional Pain Medicine (E Cornett Bradley, Section Editor)

Analgesic Techniques for Rib Fractures—A Comprehensive Review Article

Mit dem Seitenschneider gegen das Reißverschluss-Malheur

03.06.2024 Urologische Notfallmedizin Nachrichten

Wer ihn je erlebt hat, wird ihn nicht vergessen: den Schmerz, den die beim Öffnen oder Schließen des Reißverschlusses am Hosenschlitz eingeklemmte Haut am Penis oder Skrotum verursacht. Eine neue Methode für rasche Abhilfe hat ein US-Team getestet.

Blutdrucksenkung schon im Rettungswagen bei akutem Schlaganfall?

31.05.2024 Apoplex Nachrichten

Der optimale Ansatz für die Blutdruckkontrolle bei Patientinnen und Patienten mit akutem Schlaganfall ist noch nicht gefunden. Ob sich eine frühzeitige Therapie der Hypertonie noch während des Transports in die Klinik lohnt, hat jetzt eine Studie aus China untersucht.

Reanimation bei Kindern – besser vor Ort oder während Transport?

29.05.2024 Reanimation im Kindesalter Nachrichten

Zwar scheint es laut einer Studie aus den USA und Kanada bei der Reanimation von Kindern außerhalb einer Klinik keinen Unterschied für das Überleben zu machen, ob die Wiederbelebungsmaßnahmen während des Transports in die Klinik stattfinden oder vor Ort ausgeführt werden. Jedoch gibt es dabei einige Einschränkungen und eine wichtige Ausnahme.

Nicht Creutzfeldt Jakob, sondern Abführtee-Vergiftung

29.05.2024 Hyponatriämie Nachrichten

Eine ältere Frau trinkt regelmäßig Sennesblättertee gegen ihre Verstopfung. Der scheint plötzlich gut zu wirken. Auf Durchfall und Erbrechen folgt allerdings eine Hyponatriämie. Nach deren Korrektur kommt es plötzlich zu progredienten Kognitions- und Verhaltensstörungen.

Update AINS

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.