nach oben

Head and Neck Pathology

Erschienen in:

01.09.2021 | Case Reports

Polymorphous Adenocarcinoma, Low Grade Variant, Colliding with a Neurofibroma

verfasst von: Nikolaos G. Katsoulas, Konstantinos I. Tosios, Hannah Afwerke Lynch, Rachel Uppgaard, Ioannis G. Koutlas

Erschienen in: Head and Neck Pathology | Ausgabe 2/2022

Einloggen, um Zugang zu erhalten

Abstract

Collision tumors, composed of two distinct benign or malignant neoplasms, are rarely reported in the oral cavity. We present a case of a 61-year-old female with an asymptomatic non-demarcated lump on the soft palate of unknown duration. An incisional biopsy revealed the presence of two neoplastic populations, a neurofibroma that was partially infiltrated by a polymorphous adenocarcinoma, low-grade variant. Total surgical excision was performed, with uneventful follow-up period. The development of collision tumors may be incidental, although molecular events may influence the pathogenetic mechanism of the phenomenon.

Coca-Pelaz A, Triantafyllou A, Devaney KO, Rinaldo A, Takes RP, Ferlito A. Collision tumors of the larynx: a critical review. Am J Otolaryngol. 2016;37:365–8.CrossRef

Seifert G, Donath K. Hybrid tumours of salivary glands. Definition and classification of five rare cases. Eur J Cancer B Oral Oncol. 1996;32B:251–9.CrossRef

Sung CT, Shetty A, Menias CO, et al. Collision and composite tumors; radiologic and pathologic correlation. Abdom Radiol. 2017;42:2909–26.CrossRef

Peng Y, Lin J, Guan J, et al. Ovarian collision tumors: imaging findings, pathological characteristics, diagnosis, and differential diagnosis. Abdom Radiol (NY). 2018;43:2156–68.CrossRef

Schizas D, Katsaros I, Michalinos A, et al. Collision tumors of the gastrointestinal tract: a systematic review of the literature. Anticancer Res. 2018;38:6047–57.CrossRef

Brandwein-Gensler M, Urken M, Wang B. Collision tumor of the thyroid: a case report of metastatic liposarcoma plus papillary thyroid carcinoma. Head Neck. 2004;26:637–41.CrossRef

Ryan N, Walkden G, Lazic D, Tierney P. Collision tumors of the thyroid: a case report and review of the literature. Head Neck. 2015;37:E125-9.CrossRef

Sahoo NK, Sharma R, Roy ID, Kulkarni V. Collision tumor of maxilla: a diagnostic dilemma. J Maxillofac Oral Surg. 2015;14(Suppl 1):370–3.CrossRef

Takeda Y, Yamamoto H. Oral collision carcinoma: salivary duct carcinoma of minor salivary gland origin and squamous cell carcinoma of the oral mucosa. J Oral Sci. 1999;41:129–31.CrossRef

10.

Tippu SR, Rahman F, Sharma N, Srivastava S. Collision tumor of the palate: a rare case report. Contemp Clin Dent. 2014;5:102–5.CrossRef

11.

Landa LE, Kathju S, Nepomuceno-Perez MC, Gordon C, Sotereanos GC. Tuberculous granuloma and adenoid cystic carcinoma presenting as a single buccal space mass. J Craniofac Surg. 2002;13:533–7.CrossRef

12.

Maruyama M, Fushiki H, Watanabe Y. Solitary neurofibroma of the floor of the mouth: a case report. Case Rep Otolaryngol. 2011;2011:967896.PubMedPubMedCentral

13.

Chatura KR. Polymorphous low-grade adenocarcinoma. J Oral Maxillofac Pathol. 2015;19:77–82.CrossRef

14.

Liu X, Yang X, Zhan C, Zhang Y, Hou J, Yin X. Perineural invasion in adenoid cystic carcinoma of the salivary glands: where we are and where we need to go. Front Oncol. 2020;10:1493.CrossRef

15.

Alkhadar H, Macluskey M, White S, Ellis I. Nerve growth factor-induced migration in oral and salivary gland tumour cells utilises the PI3K/Akt signalling pathway: is there a link to perineural invasion? J Oral Pathol. 2020;49:227–34.CrossRef

16.

Hoshi N, Yamaki T, Hiraki H, et al. Functional nerve growth factor receptor in von Recklinghausen neurofibromatosis: an immunocytochemical and short-term culture study. Pathol Int. 1996;46:1–8.CrossRef

17.

Brown IS. Pathology of perineural spread. J Neurol Surg B Skull Base. 2016;77:124–30.CrossRef

18.

Panizza B, Warren TA, Solares CA, Boyle GM, Lambie D, Brown I. Histopathological features of clinical perineural invasion of cutaneous squamous cell carcinoma of the head and neck and the potential implications for treatment. Head Neck. 2014;36:1611–8.CrossRef

19.

Yeh I, McCalmont TH. Distinguishing neurofibroma from desmoplastic melanoma: the value of the CD34 fingerprint. J Cutan Pathol. 2011;38:625–30.CrossRef

20.

Soma L, LiVolsi VA, Baloch ZW. Dendritic interstitial and myofibroblastic cells at the border of salivary gland tumors. Arch Pathol Lab Med. 2001;125:232–6.CrossRef

21.

Kirchmann TT, Prieto VG, Smoller BR. Use of CD34 in assessing the relationship between stroma and tumor in desmoplastic keratinocytic neoplasms. J Cutan Pathol. 1995;22:422–6.CrossRef

22.

Triantafyllou A, Hunt JL, Devaney KO, Ferlito A. A perspective of comparative salivary and breast pathology. Part I: microstructural aspects, adaptations and cellular events. Eur Arch Otorhinolaryngol. 2014;271:647–63.CrossRef

Titel: Polymorphous Adenocarcinoma, Low Grade Variant, Colliding with a Neurofibroma
verfasst von: Nikolaos G. Katsoulas
Konstantinos I. Tosios
Hannah Afwerke Lynch
Rachel Uppgaard
Ioannis G. Koutlas
Publikationsdatum: 01.09.2021
Verlag: Springer US
Erschienen in: Head and Neck Pathology / Ausgabe 2/2022
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-021-01377-7

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Polymorphous Adenocarcinoma, Low Grade Variant, Colliding with a Neurofibroma

Abstract

Neu im Fachgebiet Pathologie

Assistierter Suizid durch Infusion von Thiopental

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2022

SATB2 Immunoexpression in Peripheral Ossifying Fibroma and Peripheral Odontogenic Fibroma

Diagnostic Enigma of Adenoid Ameloblastoma: Literature Review Based Evidence to Consider It as a New Sub Type of Ameloblastoma

Immunohistochemical Reactivity of Prostate-Specific Membrane Antigen in Salivary Gland Tumors

Tube/Duct-Like Configuration of Odontogenic Epithelial Rests: A Look Back to Malassez and Black

Lingual Choristoma with Gastric Epithelium Revisited

DICER1-Mutated Botryoid Fibroepithelial Polyp of the Parotid Duct: Report of the First Case

Neu im Fachgebiet Pathologie

Assistierter Suizid durch Infusion von Thiopental

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren