Background
Methods
Quantitative SPECT imaging network
Patient inclusion criteria
Data collection and imaging schedule
Dosimetry calculations
Dosimetry methodologies for dosimetry team A
Dosimetry methodologies for dosimetry team B
Whole-body dosimetry
Statistical analysis
Results
Patient characteristics
Characteristic | |
---|---|
Age—yr (mean ± standard deviation) | 47.2 ± 15.6 |
Female—N (%) (n = 105) | 79 (75.2) |
Histological subtype—N (%) | |
Papillary | 87 (82.9) |
Follicular | 15 (14.3) |
Mixed | 3 (2.9) |
Prescribed RAI activity—N (%) | |
1100 MBq | 12 (11.4) |
2500 MBq | 1 (1.0) |
3700 MBq | 92 (87.6) |
Dosimetry results
Centre 1 n = 34 | Centre 2 n = 21 | Centre 3 n = 25 | Centre 4 n = 25 | |
---|---|---|---|---|
Single-time-point patients | None | None | 25 (25 SPECT/CT, 1 per patient at 96 h) | 12 (12 SPECT/CT, 1 per patient at 24 to 48 h) |
Multiple-time-point patients (6 to 192 h) | 34 (168 SPECT scans, 4 to 6 time-points per patient between 6 and 168 h) | 21 (21 SPECT/CT and 77 SPECT scans, 4 to 6 time-points per patient between 6 and 168 h) | None | 13 (13 SPECT/CT and 25 SPECT scans, 3 time-points per patient between 24 and 72 h except for 1 patient with only 2 scans) |
Dosimetry performed by | DTB | DTA | DTA | DTA, (DTB for comparison of salivary glands only) |
Normal organ absorbed doses
Organ | Centre 1 (mGy/MBq) n = 34 | Centre 2 (mGy/MBq) n = 21 | Centre 3 (mGy/MBq) n = 25 | Centre 4 (mGy/MBq) n = 25 |
---|---|---|---|---|
Left lung | - | 0.1 (0.01–0.23) | 0.08 (0.02–0.5) | 0.11 (0.04–0.47) |
Right lung | - | 0.12 (0.01–0.44) | 0.1 (0.03–0.33) | 0.1 (0.04–0.49) |
Bones | - | 0.04 (0–0.07) | 0.03 (0.01–0.16) | 0.04 (0.02–0.08) |
Salivary glands | 0.44 (0.04–1.43) | 0.14 (0.02–0.34) | 0.05 (0.02–0.76) | 0.16 (0.03–1.07) |
Bladder wall | - | 0.19 (0.01–0.97) | 0.14 (0.02–0.66) | - |
Liver | - | 0.05 (0–0.11) | 0.05 (0–0.09) | - |
Left kidney | - | 0.06 (0–0.13) | 0.04 (0.01–0.45) | - |
Right kidney | - | 0.06 (0–0.21) | 0.04 (0.01–0.21) | - |
Spleen | - | 0.06 (0–0.15) | 0.04 (0.01–0.05) | - |
L2–L4 | - | 0.05 (0–0.1) | 0.03 (0.01–0.26) | - |
Blood | - | 0.08 (0.06–0.17) | - | - |
Whole-body | 0.04 (0.02–0.07) | 0.05 (0.03–0.08) | 0.04 (0.03–0.11) | 0.04 (0.02–0.09) |