Acta Diabetologica OnlineFirst articles

28.05.2024 | Original Article

Estimated glucose disposal rate and risk of cardiovascular disease and mortality in U.S. adults with prediabetes: a nationwide cross-sectional and prospective cohort study

The incidence of prediabetes, an intermediate stage between normal glucose metabolism and overt diabetes, is rising rapidly worldwide with an estimated global prevalence of 10.0% by 2045 [ 1 ]. It is increasingly recognized that prediabetes is an …

verfasst von:: Xiufang Kong, Wei Wang

Open Access 27.05.2024 | Original Article

Changes in vessel density patterns assessed with OCTA in patients with diabetic macular edema treated with anti-VEGF therapy

Diabetic retinopathy (DR) is characterized by microvascular changes (loss of capillary perfusion and damage to the blood-retina barrier), which can lead to the development of retinal ischemia and intraretinal exudation. These alterations are …

verfasst von:: Juan Santamaría, Estefanía Cobos, Marc Biarnes, Josep María Caminal, Ramon Rodriguez-Leor, Rahul Morwani, Manel García-Mendieta, Daniel Lorenzo, Pere García-Bru, Luis Arias

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27.05.2024 | Original Article

Association of systemic inflammation markers in cancer mortality with diabetes: evidence from National Health and Nutrition Examination Survey

The incidence of both diabetes and cancer has experienced significant increases over the past decades, with projections indicating a continued rise in newly diagnosed cases in the coming years [ 1 , 2 ]. Current estimates suggest that approximately …

verfasst von:: Wenjie Li, Peixin Dong, Wei Wang

Open Access 26.05.2024 | Original Article

Screening for undiagnosed pancreatic exocrine insufficiency (PEI) in a cohort of diabetic patients using faecal elastase testing and PEI scoring system

Diabetes mellitus (DM) is caused by a relative or absolute deficiency of insulin secretion resulting in hyperglycaemia. Besides causing life-threatening complications, it can also result in abnormalities of the exocrine pancreatic gland. The …

verfasst von:: V. Parihar, R. Ballester, P. F. Ridgway, K. C. Conlon, J. Gibney, B. M. Ryan

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26.05.2024 | Original Article

Structural and functional characterization of retinal impairment in T1DM patients without diabetic retinopathy: a 3-year longitudinal study

Diabetic retinopathy (DR) is a severe burden on the global working-age population. One of the main predisposing factors for the onset and progression of DR is long-term illness [1] . It is recognized that type 1 diabetes (T1DM) showed a greater …

verfasst von:: Riccardo Sacconi, Beatrice Tombolini, Antonio Cartabellotta, Gianpaolo Zerbini, Francesco Bandello, Giuseppe Querques

Open Access 24.05.2024 | Original Article

Association between sodium–glucose cotransporter-2 (SGLT2) inhibitors and macular degeneration in patients with diabetes: a nationwide population-based study in Taiwan

A novel type of drug, sodium-glucose cotransporter-2 (SGLT2) inhibitors, has been approved for diabetes treatment by the U.S. Food and Drug Administration (FDA) since 2014 [ 1 ]. SGLT2 is primarily expressed in the proximal convoluted tubule and …

verfasst von:: Min-Yen Hsu, Kai-Shin Luo, Chien-Chih Chou, Yu-Hsiang Lin, Yu-Chien Hung, Wu-Lung Chuang, Stella Chin-Shaw Tsai, Heng-Jun Lin, Teng-Shun Yu, Fuu-Jen Tsai, Kuang-Hsi Chang

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24.05.2024 | Original Article

Effectiveness of switching from first-generation basal insulin to Glargine 300 U/mL in children and adolescents with type 1 diabetes: results from the ISPED CARD database

In the treatment of children and adolescents with type 1 diabetes (T1D), the achievement and maintenance of good glycemic control play a key role in delaying or reducing the risk of acute complications and microvascular and macrovascular …

verfasst von:: Maria Chiara Rossi, Riccardo Bonfanti, Giusi Graziano, Monica Larosa, Fortunato Lombardo, Antonio Nicolucci, Giacomo Vespasiani, Stefano Zucchini, Ivana Rabbone, the ISPED CARD Study Group

24.05.2024 | Original Article

Peripapillary microvasculature and retinal nerve fiber layer damage according to the severity of diabetic retinopathy

Diabetic retinopathy (DR), a representative microvascular complication of type 2 diabetes mellitus (T2DM), is a leading cause of legal blindness in the working-age population worldwide [ 1 ]. DR can cause diabetic macular edema, vitreous …

verfasst von:: Min-Woo Lee, Jung-Tae Kim, Hyun-Je Seong, Ki-Yup Nam

23.05.2024 | Original Article

Comprehensive assessment of ocular parameters for identifying diagnostic indicators of diabetic peripheral neuropathy

Diabetes represents a global health burden, with the prevalence of 10.5% in adults aged 20–79 in 2021 according to the IDF Diabetes Atlas (2021) [ 1 ]. The chronic condition is accompanied by a range of complications, including diabetic …

verfasst von:: Yesheng Chen, Zhicong Xu, Anyi Liang, Ruoyu Chen, Zicheng Wang, Xiaojun Chen, Kangyan Zheng, Peiyao Lu, Huilin Liang, Dan Cao, Liang Zhang

22.05.2024 | Original Article

Temporal trends in the visual impairment burden attributable to high fasting plasma glucose levels: a population-based study

Elevated fasting plasma glucose (FPG) level, a manifestation of diabetes reflecting insufficient glycaemic control, is one of the five primary risk factors impacting human health with increasing prevalence worldwide [ 1 ]. Prolonged poor glycaemic …

verfasst von:: Jianqi Chen, Xiaohong Chen, Zhidong Li, Xuhao Chen, Shaofen Huang, Guitong Ye, Rui Xie, Ruiyu Luo, Yuan Zhang, Xinyue Shen, Yehong Zhuo, Shengsong Huang, Yiqing Li, Yingting Zhu

20.05.2024 | Original Article

Assessment of genetic and clinical factors in T2D susceptibility among patients with hypertension

Type 2 Diabetes (T2D) and hypertension (HTN) often coexist in the same patient, thus amplifying the risk of cardiovascular incidents and micro and macroangiopathies in the whole organism. Prospective studies have suggested a reciprocal …

verfasst von:: Cynthia Al Hageh, Siobhán O’Sullivan, Andreas Henschel, Stephanie Chacar, Mireille Hantouche, Moni Nader, Pierre A. Zalloua

Open Access 20.05.2024 | Original Article

Open questions on basal insulin therapy in T2D: a Delphi consensus

Insulin is useful and valuable to maintain glycemic control once progression of the disease overcomes the effect of other glucose-lowering agents [ 1 ]. Thus, many adults with type 2 diabetes (T2D) eventually require and benefit from insulin …

verfasst von:: Raffaella Buzzetti, Riccardo Candido, Katherine Esposito, Andrea Giaccari, Edoardo Mannucci, Antonio Nicolucci, Giuseppina T. Russo, Delphi Board

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Open Access 18.05.2024 | Original Article

An “out of the box” approach for prevention of ketoacidosis in youth with poorly controlled type 1 diabetes: combined use of insulin pump and long-acting insulin

Managing type 1 diabetes (T1D) in pediatric as well as adults remains a significant challenge for patients and caregivers. Only a minority of people living with T1D meet widely accepted glycemic goals, though it should be noted that studies with …

verfasst von:: Galia Barash, Liat Lerman, Tal Ben-Ari, Shirly Abiri, Zohar Landau, Michal Ben Ami, Avivit Brener, Yael Lebenthal, Orit Pinhas-Hamiel, Kineret Mazor-Aronovitch, Alon Haim, Yonatan Yeshayahu, Liat De Vries, Marianna Rachmiel

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18.05.2024 | Original Article

Relationship between immune cells and diabetic nephropathy: a Mendelian randomization study

Diabetic nephropathy (DN) is the most common microvascular complication of diabetes. According to the latest Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), there were approximately 529 million people with diabetes globally in …

verfasst von:: Xin Li, Liangyou Zhang, Chuang Yan, Huo Zeng, Gangyi Chen, Jianwen Qiu

16.05.2024 | Original Article

Risk of cardiovascular events after gestational diabetes: a retrospective population study

Gestational diabetes (GDM) is significantly associated with increased risk of type 2 diabetes and of cardiovascular diseases (CVD) after pregnancy [ 1 – 5 ]. Open, however, remains the question whether the augmented risk of CVD is driven directly …

verfasst von:: Giuseppe Seghieri, Elisa Gualdani, Ilaria Campesi, Flavia Franconi, Paolo Francesconi, Graziano Di Cianni

Open Access 14.05.2024 | Original Article

Sex-driven factors associated with anxiety and depression in autoimmune diabetes

Patients with autoimmune diabetes mellitus need a lifetime replacement with exogenous insulin, and the maintenance of adequate glycemic control is considered essential for limiting the risk of diabetes-related acute and chronic complications [ 1 ].

verfasst von:: Enrico Saudelli, Simona Moscatiello, Michele Baldari, Claudio Bongiorno, Stefano Zucchini, Giulio Maltoni, Alessandro Agostini, Alexandro Paccapelo, Elena Nardi, Danilo Ribichini, Alessia Bruco, Valentina Lo Preiato, Gilberto Laffi, Uberto Pagotto, Guido Di Dalmazi

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Open Access 13.05.2024 | Original Article

The interplay between excess weight and hyper-glycemia on NCDs in Italy: results from a cross-sectional study

The continuing growth in the prevalence of overweight and obesity is a cause of serious concern in all regions of the world, and the phenomenon is increasingly taking the form of a global pandemic. In 2015, a total of 603.7 million adults were …

verfasst von:: Vincenzo Atella, Federico Belotti, Matilde Giaccherini, Gerardo Medea, Andrea Piano Mortari, Paolo Sbraccia, Antonio Nicolucci

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11.05.2024 | Original Article

Association between hemoglobin A1c trajectory during pregnancy and adverse birth outcomes among non-gestational diabetic women

Hyperglycemia during pregnancy is a well-recognized risk factor for adverse maternal and fetal outcomes in the short and long term [ 1 , 2 ]. Maternal hyperglycemia during pregnancy can increase the risk of adverse birth outcomes such as preterm …

verfasst von:: Jing Peng, Li Zhang, Lijuan Zheng, Zixia Mai, Lulu Song, Qing Liu, Jianing Bi, Xiya Qin, Qing Fang, Guozhen Chen, Gaojie Fan, Guocheng Liu, Youjie Wang

Open Access 08.05.2024 | Original Article

Reduced expression of central innate defense molecules in pancreatic biopsies from subjects with Type 1 diabetes

Defensins are small molecules (2–5 kDa) that play an important role in the innate and adaptive defence system. They belong to a large family of antimicrobial peptides of ancient conservation. Humans express two subfamilies, Alpha- and …

verfasst von:: Angie Tegehall, Sofie Ingvast, Lars Krogvold, Knut Dahl-Jørgensen, Olle Korsgren

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07.05.2024 | Original Article

A comprehensive meta-analysis on the association of SGLT2is and GLP-1RAs with vascular diseases, digestive diseases and fractures

Glucagon-like peptide 1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) are two new kinds of antidiabetic agents. Apart from their glucose-lowering effects, they are able to significantly reduce cardio-renal …

verfasst von:: De-Hua Wang, Yu-Xia Mo, Xiang Tan, Ji-Yong Xie, Huan Wang, Fei Wen

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