Penile cancer (PeCa) is a rare disease in industrial countries with a worldwide incidence of 0.08/100.000 [ 1 ]. 5-year overall survival is 95% for localized disease and drops to 35–80% in pN + patients [ 2 ]. Patients with ≥ pT1b and cN0 status on …
verfasst von:
Lennert Eismann, Stephan T. Ledderose, Benazir Enzinger, Elena Berg, Thilo Westhofen, Severin Rodler, Gerald B. Schulz, Johannes Toms, Adrien Holzgreve, Franz J. Gildehaus, Matthias Brendel, Clemens C. Cyran, Marcus Unterrainer, Christian G. Stief, Peter Bartenstein, Boris Schlenker, Lena M. Unterrainer
About 1% of the global population suffers from epilepsy [ 1 ], and for approximately 30% of the patients, anti-seizure medication (ASM) does not lead to seizure freedom [ 2 ]. Levetiracetam (LEV) is a very commonly used ASM approved for the …
verfasst von:
Maja R. Marstrand-Joergensen, Gjertrud L. Laurell, Susan Herrmann, Arafat Nasser, Annette Johansen, Anton Lund, Thomas L. Andersen, Gitte M. Knudsen, Lars H. Pinborg
Fibroblasts are the most common component of connective tissues and are found throughout the body [ 1 ]. In normal tissues, they are resting mesenchymal cells in the extracellular matrix (ECM). Normal activated fibroblasts (NAF) aid in repair and …
verfasst von:
Peter George Maliha, Masatoshi Hotta, Andrea Farolfi, Tristan Grogan, Rejah Alano, Andrea Limon, Ethan Lam, Giuseppe Carlucci, Shadfar Bahri, Ali Salavati, Matthias Benz, Daniel Silverman, Pawan Gupta, Andrew Quon, Martin Allen-Auerbach, Johannes Czernin, Jeremie Calais
(endorsed by the ACR, ESSO, ESTRO, EUSOBI/ESR, and EUSOMA)
The aim of this guideline is to provide information regarding the role of 2-[ 18 F]fluoro-2-deoxy- D -glucose positron emission tomography/computed tomography (2-[ 18 F]FDG PET/CT) in patients with no special type breast cancer (NST BC) …
verfasst von:
Sofia C. Vaz, John Patrick Pilkington Woll, Fatima Cardoso, David Groheux, Gary J. R. Cook, Gary A. Ulaner, Heather Jacene, Isabel T. Rubio, Jan W. Schoones, Marie-Jeanne Vrancken Peeters, Philip Poortmans, Ritse M. Mann, Stephanie L. Graff, Elizabeth H. Dibble, Lioe-Fee de Geus-Oei
Gianpaolo Di Santo, Giulia Santo, Vladan Martinovic, Dominik Wolf, Andreas Pircher, Anna Sviridenko, Judith Löffler-Ragg, Elisabeth von Guggenberg, Irene Virgolini
[18F]FDG PET/CT is an established modality of tumour staging. In the multicentre study PETABC, 369 patients with invasive ductal carcinoma and clinical TNM stage III or IIB were randomly assigned to receive either [18F]FDG PET/CT imaging or …
Brain functional and physiological plasticity is essential to combat dynamic environmental challenges, for survival and the wellbeing. This includes the potential seasonal patterns of dopamine signaling. For instance, in vivo imaging data in both …
verfasst von:
Lihua Sun, Tuulia Malén, Jouni Tuisku, Valtteri Kaasinen, Jarmo A. Hietala, Juha Rinne, Pirjo Nuutila, Lauri Nummenmaa
Coronary artery bypass grafting (CABG) is the preferred therapeutic intervention for individuals with extensive coronary artery disease (CAD) [ 1 , 2 ]. The emergence of perioperative myocardial infarction (PMI) can increase the risk of …
Several inhibitory immune checkpoint proteins have been identified, along with their corresponding ligands found on various cells, including dendritic cells and tumour cells. These immune checkpoint proteins engage in interactions with their …
verfasst von:
Zhipeng Cao, Christian Werner Wichmann, Ingrid Julienne Georgette Burvenich, Laura Danielle Osellame, Nancy Guo, Angela Rigopoulos, Graeme Joseph O’Keefe, Fiona Elizabeth Scott, Nirmal Lorensuhewa, Kevin Patrick Lynch, Andrew Mark Scott
[ 123 I]I-FP-CIT SPECT is a well-validated imaging tool to investigate the integrity of the dopaminergic nigrostriatal pathway in parkinsonian patients by targeting the dopamine transporter (DAT) [ 1 ]. In routine practice, analysis of [ 123 …
verfasst von:
Jan Booij, Eda Yağci, Zulfiqar H Sheikh, Youssef Chahid
Nasopharyngeal carcinoma (NPC) is an epithelial malignancy which is characterized by distinct global geographical distribution [ 1 ]. It is notably common in east and southeast Asia, and remains a considerable cause of cancer-related deaths [ 2 ].
verfasst von:
Jieling Zheng, Guochang Wang, Qian Ru, Yun Yang, Li Su, Wenlong Lv, Chunlin Ke, Peirong Wang, Xiaohui Liu, Li Zhang, Feng Liu, Weibing Miao
Cancer-associated fibroblasts (CAFs) are critical players in the tumor microenvironment. Fibroblast activation protein (FAP), a membrane-bound serine protease that is overexpressed in most epithelial tumors, is one of the critical targets of CAFs …
Chimeric antigen receptor (CAR) cell therapies utilize CARs to redirect immune cells towards cancer cells expressing specific antigens like human epidermal growth factor receptor 2 (HER2). Despite their potential, CAR T cell therapies exhibit …
verfasst von:
Nourhan Shalaby, Ying Xia, John J Kelly, Rafael Sanchez-Pupo, Francisco Martinez, Matthew S Fox, Jonathan D Thiessen, Justin W Hicks, Timothy J Scholl, John A. Ronald
Radiopharmaceuticals therapy (RPT) is a contemporary approach to radiation oncology, which aims to deliver the maximally destructive radiation dose via cancer-targeting radiopharmaceutical [ 1 ]. In the last decades, advances in molecular biology …
verfasst von:
Song Xue, Andrei Gafita, Yu Zhao, Lorenzo Mercolli, Fangxiao Cheng, Isabel Rauscher, Calogero D’Alessandria, Robert Seifert, Ali Afshar-Oromieh, Axel Rominger, Matthias Eiber, Kuangyu Shi
Lung cancer remains the predominant cause of cancer-related mortality worldwide and ranks the most common cancer globally [ 1 ]. The advent of widespread lung cancer screening has markedly elevated the detection rates of early-stage lung cancer [ 2 …,
With the dramatic rise in the availability and abuse of illicit opioids, the mortality rate of overdose associated with opioid use disorder has reached epidemic proportions in the world [ 1 , 2 ], particularly the United States [ 3 , 4 ]. Most of …
verfasst von:
Chia-Ju Hsieh, Catherine Hou, Hsiaoju Lee, Cosette Tomita, Alexander Schmitz, Konstantinos Plakas, Jacob G. Dubroff, Robert H. Mach
Radioligand therapy (RLT) with particle-emitting radionuclides such as 177 Lu or 225 Ac for tumor therapy arguably had the greatest impact on the practice of nuclear medicine in the last ten years [ 1 ]. Ideally, such radiopharmaceuticals are …
verfasst von:
Stefan Stangl, Nghia Trong Nguyen, Julia Brosch-Lenz, Jakub Šimeček, Wolfgang A. Weber, Susanne Kossatz, Johannes Notni
