Erschienen in:
12.12.2023 | Übersicht
HLA-B27-positive anterior uveitis
Clinical aspects, diagnostics, interdisciplinary management, and treatment
verfasst von:
Peter Werkl, Judith Rademacher, Prof. Dr. med. Uwe Pleyer, FEBO
Erschienen in:
Die Ophthalmologie
|
Sonderheft 1/2024
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Abstract
Acute anterior uveitis (AAU) associated with human leukocyte antigen (HLA) B27 is the most common form of noninfectious intraocular inflammation and is considered to be a separate clinical entity. Young adults between the ages of 20 and 40 years are predominantly affected. The HLA-B27 positive AAU typically presents as a unilateral, fulminant disruption of the blood-aqueous humor barrier, which is accompanied by pronounced cellular infiltration and fibrinous exudation. Other characteristics are reduced intraocular pressure and a high tendency to relapse, which can also involve the partner eye. Patients with HLA-B27 positive AAU share a high risk for other genetically associated diseases, especially spondylarthritis, chronic inflammatory bowel diseases and psoriasis. As up to 40% of those affected have a systemic disease that has not yet been diagnosed, the ophthalmologist is of major importance for early detection.