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Erschienen in: Current Pain and Headache Reports 10/2023

11.08.2023 | Chronic Daily Headache (S-J Wang and S-P Chen, Section Editors)

Hemicrania Continua: An Update

verfasst von: Haidar M. Al-Khazali, Rune Häckert Christensen, Giorgio Lambru, David W. Dodick, Håkan Ashina

Erschienen in: Current Pain and Headache Reports | Ausgabe 10/2023

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Abstract

Purpose of Review

Hemicrania Continua (HC) is a rare and disabling primary headache disorder that is characterized by persistent, unilateral headache with ipsilateral, cranial autonomic symptoms and restlessness or agitation. The diagnosis requires patients to experience an absolute response to therapeutic doses of indomethacin.

Recent Findings

HC is diagnosed in in about 1.8% of adult patients who were evaluated for headache in tertiary care services, albeit this estimate should be interpreted with caution. The most prevalent accompanying symptoms appear to be lacrimation, conjunctival injection and restlessness or agitation. However, the available literature is limited by methodologic issues, and the current diagnostic criteria lack clarity on what defines absolute response to indomethacin. More rigorous studies are thus needed to improve our understanding of HC which, in turn, will facilitate better disease management in clinical practice.

Summary

Here, we provide a comprehensive overview of HC, including its epidemiology, clinical presentation, diagnostic evaluation, and management.
Literatur
1.
Zurück zum Zitat • Diener HC, Tassorelli C, Dodick DW. Management of Trigeminal Autonomic Cephalalgias Including Chronic Cluster. JAMA Neurol. 2023;80:308. This reference provides an overview of TACs, including how to differentiate between HC and other differential diagnoses.CrossRef • Diener HC, Tassorelli C, Dodick DW. Management of Trigeminal Autonomic Cephalalgias Including Chronic Cluster. JAMA Neurol. 2023;80:308. This reference provides an overview of TACs, including how to differentiate between HC and other differential diagnoses.CrossRef
2.
Zurück zum Zitat Hryvenko I, Cervantes-Chavarría AR, Law AS, Nixdorf DR. Hemicrania continua: Case series presenting in an orofacial pain clinic. Cephalalgia. 2018;38:1950–9.CrossRefPubMed Hryvenko I, Cervantes-Chavarría AR, Law AS, Nixdorf DR. Hemicrania continua: Case series presenting in an orofacial pain clinic. Cephalalgia. 2018;38:1950–9.CrossRefPubMed
3.
Zurück zum Zitat Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38:1–211. Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38:1–211.
4.
Zurück zum Zitat • Al-Khazali HM, Al-Khazali S, Iljazi A, Christensen RH, Ashina S, Lipton RB, et al. Prevalence and clinical features of hemicrania continua in clinic-based studies: A systematic review and meta-analysis. Cephalalgia. 2023;43:033310242211313. This reference estimates the relative frequencies of hemicrania continua and its clinical features in among people who were evaluated for headache in a clinic-based setting. • Al-Khazali HM, Al-Khazali S, Iljazi A, Christensen RH, Ashina S, Lipton RB, et al. Prevalence and clinical features of hemicrania continua in clinic-based studies: A systematic review and meta-analysis. Cephalalgia. 2023;43:033310242211313. This reference estimates the relative frequencies of hemicrania continua and its clinical features in among people who were evaluated for headache in a clinic-based setting.
5.
Zurück zum Zitat Wei DY, Goadsby PJ. Recent Advances and Updates in Trigeminal Autonomic Cephalalgias. Semin Neurol. 2022;42:474–8.CrossRefPubMed Wei DY, Goadsby PJ. Recent Advances and Updates in Trigeminal Autonomic Cephalalgias. Semin Neurol. 2022;42:474–8.CrossRefPubMed
6.
Zurück zum Zitat Peres MFP, Silberstein SD, Nahmias S, Shechter AL, Youssef I, Rozen TD, et al. Hemicrania continua is not that rare. Neurology. 2001;57:948–51.CrossRefPubMed Peres MFP, Silberstein SD, Nahmias S, Shechter AL, Youssef I, Rozen TD, et al. Hemicrania continua is not that rare. Neurology. 2001;57:948–51.CrossRefPubMed
8.
Zurück zum Zitat Prakash S, Rathore C, Rana K, Joshi H, Patel J, Rawat KS. A long-term prospective observational study in 31 patients with hemicrania continua. Cephalalgia Rep. 2019;2:251581631882469.CrossRef Prakash S, Rathore C, Rana K, Joshi H, Patel J, Rawat KS. A long-term prospective observational study in 31 patients with hemicrania continua. Cephalalgia Rep. 2019;2:251581631882469.CrossRef
9.
Zurück zum Zitat Prakash S, Rawat K. Hemicrania Continua: An Update. Neurol India. 2021;69:160.CrossRef Prakash S, Rawat K. Hemicrania Continua: An Update. Neurol India. 2021;69:160.CrossRef
10.
Zurück zum Zitat Prakash S, Golwala P. A proposal for revision of hemicrania continua diagnostic criteria based on critical analysis of 62 patients. Cephalalgia. 2012;32:860–8.CrossRefPubMed Prakash S, Golwala P. A proposal for revision of hemicrania continua diagnostic criteria based on critical analysis of 62 patients. Cephalalgia. 2012;32:860–8.CrossRefPubMed
11.
Zurück zum Zitat Cittadini E, Goadsby PJ. Hemicrania continua: a clinical study of 39 patients with diagnostic implications. Brain. 2010;133:1973–86.CrossRefPubMed Cittadini E, Goadsby PJ. Hemicrania continua: a clinical study of 39 patients with diagnostic implications. Brain. 2010;133:1973–86.CrossRefPubMed
12.
13.
Zurück zum Zitat Ziegeler C, May A. Facial presentations of migraine, TACs, and other paroxysmal facial pain syndromes. Neurology. 2019;93:e1138–47.CrossRefPubMed Ziegeler C, May A. Facial presentations of migraine, TACs, and other paroxysmal facial pain syndromes. Neurology. 2019;93:e1138–47.CrossRefPubMed
14.
Zurück zum Zitat May A. Cluster headache: pathogenesis, diagnosis, and management. Lancet. 2005;366:843–55. May A. Cluster headache: pathogenesis, diagnosis, and management. Lancet. 2005;366:843–55.
15.
Zurück zum Zitat Ashina M, Terwindt GM, Al-Karagholi MA-M, de Boer I, Lee MJ, Hay DL, et al. Migraine: disease characterisation, biomarkers, and precision medicine. Lancet. 2021;397:1496–504. Ashina M, Terwindt GM, Al-Karagholi MA-M, de Boer I, Lee MJ, Hay DL, et al. Migraine: disease characterisation, biomarkers, and precision medicine. Lancet. 2021;397:1496–504.
16.
Zurück zum Zitat Rasmussen BK, Jensen R, Olesen J. A Population-Based Analysis of the Diagnostic Criteria of the International Headache Society. Cephalalgia. 1991;11:129–34.CrossRefPubMed Rasmussen BK, Jensen R, Olesen J. A Population-Based Analysis of the Diagnostic Criteria of the International Headache Society. Cephalalgia. 1991;11:129–34.CrossRefPubMed
17.
Zurück zum Zitat Munjal S, Singh P, Reed ML, Fanning K, Schwedt TJ, Dodick DW, et al. Most bothersome symptom in persons with migraine: results from the migraine in america symptoms and treatment (MAST) Study. Headache: J Head Face Pain. 2020;60:416–29. Munjal S, Singh P, Reed ML, Fanning K, Schwedt TJ, Dodick DW, et al. Most bothersome symptom in persons with migraine: results from the migraine in america symptoms and treatment (MAST) Study. Headache: J Head Face Pain. 2020;60:416–29.
18.
Zurück zum Zitat Christensen CG, Techlo TR, Kogelman LJ, Wegner Thørner L, Nissen J, Sørensen E, et al. Population-based prevalence of cranial autonomic symptoms in migraine and proposed diagnostic appendix criteria. Cephalalgia. 2022;42:1160–71.CrossRefPubMed Christensen CG, Techlo TR, Kogelman LJ, Wegner Thørner L, Nissen J, Sørensen E, et al. Population-based prevalence of cranial autonomic symptoms in migraine and proposed diagnostic appendix criteria. Cephalalgia. 2022;42:1160–71.CrossRefPubMed
20.
Zurück zum Zitat Peng K-P, Fuh J-L, Yuan H-K, Shia B-C, Wang S-J. New daily persistent headache: Should migrainous features be incorporated? Cephalalgia. 2011;31:1561–9.CrossRefPubMed Peng K-P, Fuh J-L, Yuan H-K, Shia B-C, Wang S-J. New daily persistent headache: Should migrainous features be incorporated? Cephalalgia. 2011;31:1561–9.CrossRefPubMed
21.
Zurück zum Zitat Rozen TD. New daily persistent headache (NDPH) triggered by a single Valsalva event: A case series. Cephalalgia. 2019;39:785–91.CrossRefPubMed Rozen TD. New daily persistent headache (NDPH) triggered by a single Valsalva event: A case series. Cephalalgia. 2019;39:785–91.CrossRefPubMed
22.
Zurück zum Zitat Matharu MS, Cohen AS, McGonigle DJ, Ward N, Frackowiak RS, Goadsby PJ. Posterior hypothalamic and brainstem activation in hemicrania continua. Headache: J Head Face Pain. 2004;44:747–61. Matharu MS, Cohen AS, McGonigle DJ, Ward N, Frackowiak RS, Goadsby PJ. Posterior hypothalamic and brainstem activation in hemicrania continua. Headache: J Head Face Pain. 2004;44:747–61.
23.
Zurück zum Zitat Marek S, Tervo-Clemmens B, Calabro FJ, Montez DF, Kay BP, Hatoum AS, et al. Publisher Correction: Reproducible brain-wide association studies require thousands of individuals. Nature. 2022;605:E11–E11.CrossRefPubMedPubMedCentral Marek S, Tervo-Clemmens B, Calabro FJ, Montez DF, Kay BP, Hatoum AS, et al. Publisher Correction: Reproducible brain-wide association studies require thousands of individuals. Nature. 2022;605:E11–E11.CrossRefPubMedPubMedCentral
24.
Zurück zum Zitat Baraldi C, Pellesi L, Guerzoni S, Cainazzo MM, Pini LA. Therapeutical approaches to paroxysmal hemicrania, hemicrania continua and short lasting unilateral neuralgiform headache attacks: a critical appraisal. J Headache Pain. 2017;18:71.CrossRefPubMedPubMedCentral Baraldi C, Pellesi L, Guerzoni S, Cainazzo MM, Pini LA. Therapeutical approaches to paroxysmal hemicrania, hemicrania continua and short lasting unilateral neuralgiform headache attacks: a critical appraisal. J Headache Pain. 2017;18:71.CrossRefPubMedPubMedCentral
25.
Zurück zum Zitat Antonaci F, Pareja JA, Caminero AB, Sjaastad O. Chronic Paroxysmal Hemicrania and Hemicrania Continua. Parenteral Indomethacin: The “Indotest.” Headache: J Head Face Pain. 1998;38:122–8. Antonaci F, Pareja JA, Caminero AB, Sjaastad O. Chronic Paroxysmal Hemicrania and Hemicrania Continua. Parenteral Indomethacin: The “Indotest.” Headache: J Head Face Pain. 1998;38:122–8.
26.
Zurück zum Zitat Pareja JA, Sjaastad O. Chronic paroxysmal hemicrania and hemicrania continua. interval between indomethacin administration and response. Headache: J Head Face Pain. 1996;36:20–3. Pareja JA, Sjaastad O. Chronic paroxysmal hemicrania and hemicrania continua. interval between indomethacin administration and response. Headache: J Head Face Pain. 1996;36:20–3.
27.
Zurück zum Zitat Marmura M, Silberstein S, Gupta M. Hemicrania continua: who responds to Indomethacin? Cephalalgia. 2009;29:300–7.CrossRefPubMed Marmura M, Silberstein S, Gupta M. Hemicrania continua: who responds to Indomethacin? Cephalalgia. 2009;29:300–7.CrossRefPubMed
28.
Zurück zum Zitat Pareja J, Caminero A, Franco E, Casado J, Pascual J, del Río MS. Dose, efficacy and tolerability of long-term indomethacin treatment of chronic paroxysmal hemicrania and hemicrania continua. Cephalalgia. 2001;21:906–10.CrossRefPubMed Pareja J, Caminero A, Franco E, Casado J, Pascual J, del Río MS. Dose, efficacy and tolerability of long-term indomethacin treatment of chronic paroxysmal hemicrania and hemicrania continua. Cephalalgia. 2001;21:906–10.CrossRefPubMed
29.
Zurück zum Zitat Rozen TD. How effective is melatonin as a preventive treatment for hemicrania continua? a clinic-based study. Headache: J Head Face Pain. 2015;55:430–6. Rozen TD. How effective is melatonin as a preventive treatment for hemicrania continua? a clinic-based study. Headache: J Head Face Pain. 2015;55:430–6.
30.
Zurück zum Zitat Peres MFP, Silberstein SD. Hemicrania continua responds to cyclooxygenase‐2 Inhibitors. Headache: J Head Face Pain. 2002;42:530–1. Peres MFP, Silberstein SD. Hemicrania continua responds to cyclooxygenase‐2 Inhibitors. Headache: J Head Face Pain. 2002;42:530–1.
31.
Zurück zum Zitat Miller S, Correia F, Lagrata S, Matharu MS. OnabotulinumtoxinA for Hemicrania Continua: open label experience in 9 patients. J Headache Pain. 2015;16:19.CrossRefPubMedPubMedCentral Miller S, Correia F, Lagrata S, Matharu MS. OnabotulinumtoxinA for Hemicrania Continua: open label experience in 9 patients. J Headache Pain. 2015;16:19.CrossRefPubMedPubMedCentral
32.
Zurück zum Zitat Antonaci F, Pareja JA, Caminero AB, Sjaastad O. Chronic paroxysmal hemicrania and hemicrania continua: anaesthetic blockades of pericranial nerves. Funct Neurol. 1997;12:11–5.PubMed Antonaci F, Pareja JA, Caminero AB, Sjaastad O. Chronic paroxysmal hemicrania and hemicrania continua: anaesthetic blockades of pericranial nerves. Funct Neurol. 1997;12:11–5.PubMed
33.
34.
Zurück zum Zitat Brighina F, Palermo A, Cosentino G, Fierro B. Prophylaxis of hemicrania continua: two new cases effectively treated with topiramate. Headache: J Head Face Pain. 2007;47:441–3. Brighina F, Palermo A, Cosentino G, Fierro B. Prophylaxis of hemicrania continua: two new cases effectively treated with topiramate. Headache: J Head Face Pain. 2007;47:441–3.
35.
Zurück zum Zitat Camarda C, Camarda R, Monastero R. Chronic paroxysmal hemicrania and hemicrania continua responding to topiramate: Two case reports. Clin Neurol Neurosurg. 2008;110:88–91.CrossRefPubMed Camarda C, Camarda R, Monastero R. Chronic paroxysmal hemicrania and hemicrania continua responding to topiramate: Two case reports. Clin Neurol Neurosurg. 2008;110:88–91.CrossRefPubMed
37.
Zurück zum Zitat Prakash S, Husain M, Sureka DS, Shah NP, Shah ND. Is there need to search for alternatives to indomethacin for hemicrania continua? Case reports and a review. J Neurol Sci. 2009;277:187–90.CrossRefPubMed Prakash S, Husain M, Sureka DS, Shah NP, Shah ND. Is there need to search for alternatives to indomethacin for hemicrania continua? Case reports and a review. J Neurol Sci. 2009;277:187–90.CrossRefPubMed
38.
39.
Zurück zum Zitat Trimboli M, Al-Kaisy A, Andreou AP, Murphy M, Lambru G. Non-invasive vagus nerve stimulation for the management of refractory primary chronic headaches: A real-world experience. Cephalalgia. 2018;38:1276–85.CrossRefPubMed Trimboli M, Al-Kaisy A, Andreou AP, Murphy M, Lambru G. Non-invasive vagus nerve stimulation for the management of refractory primary chronic headaches: A real-world experience. Cephalalgia. 2018;38:1276–85.CrossRefPubMed
40.
Zurück zum Zitat Villar‐Martínez MD, Moreno‐Ajona D, Chan C, Goadsby PJ. Indomethacin‐responsive headaches—A narrative review. Headache: J Head Face Pain. 2021;61:700–14. Villar‐Martínez MD, Moreno‐Ajona D, Chan C, Goadsby PJ. Indomethacin‐responsive headaches—A narrative review. Headache: J Head Face Pain. 2021;61:700–14.
41.
Zurück zum Zitat Barbanti P, Fabbrini G, Pesare M, Vanacore N, Cerbo R. Unilateral cranial autonomic symptoms in migraine. Cephalalgia. 2002;22:256–9.CrossRefPubMed Barbanti P, Fabbrini G, Pesare M, Vanacore N, Cerbo R. Unilateral cranial autonomic symptoms in migraine. Cephalalgia. 2002;22:256–9.CrossRefPubMed
42.
Zurück zum Zitat González-Quintanilla V, Pérez-Pereda S, Fontanillas N, Pascual J. First case of hemicrania continua responsive to galcanezumab. Neurol Sci. 2021;42:4775–6.CrossRefPubMed González-Quintanilla V, Pérez-Pereda S, Fontanillas N, Pascual J. First case of hemicrania continua responsive to galcanezumab. Neurol Sci. 2021;42:4775–6.CrossRefPubMed
Metadaten
Titel
Hemicrania Continua: An Update
verfasst von
Haidar M. Al-Khazali
Rune Häckert Christensen
Giorgio Lambru
David W. Dodick
Håkan Ashina
Publikationsdatum
11.08.2023
Verlag
Springer US
Erschienen in
Current Pain and Headache Reports / Ausgabe 10/2023
Print ISSN: 1531-3433
Elektronische ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-023-01156-9

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