Erschienen in:
10.01.2024 | Editorial
Glymphatic imaging: a critical look at the DTI-ALPS index
verfasst von:
Geir Ringstad
Erschienen in:
Neuroradiology
|
Ausgabe 2/2024
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Excerpt
Derived from rodent studies, the glymphatic system was described in 2012 as a pathway facilitating perivascular clearance of solutes from the brain interstitial fluid (ISF) [
1]. The term “glymphatic” is an abbreviation for glia-lymphatic, reflecting the presence of glial cells (astrocytic end feet) that ensheath all brain blood vessels, creating a pseudo-lymphatic system. The glymphatic clearance process is facilitated by an influx of cerebrospinal fluid (CSF) from the brain’s surface along penetrating arteries, leading to an exchange with ISF (CSF-ISF exchange), followed by subsequent clearance of solutes from the brain along veins. Glymphatic activity is associated with sleep, also in humans [
2], and its clearance function concerns primarily endogenous waste products such as amyloid-β and hyperphosphorylated tau, which accumulate in various neurodegenerative disorders [
3]. …