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07.04.2022 | Sine qua non Radiology-Pathology

Ghost Cell Odontogenic Carcinoma Arising in a Previous Calcifying Odontogenic Cyst: A Case Report and Review of Literature

verfasst von: Ioana Ghita, Michael Y. Nagai, Joshua E. Lubek, Kristen M. Stashek, John R. Basile, Jeffery B. Price, John C. Papadimitriou, Donita Dyalram, Rania H. Younis

Erschienen in: Head and Neck Pathology | Ausgabe 3/2022

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Abstract

Ghost cell odontogenic carcinoma (GCOC) is a rare malignant tumor of odontogenic origin, with only about 50 cases reported in the English literature so far. Histologically, it is characterized by ghost cells, dentinoid deposits, high grade malignant cellular features, and areas of necrosis and invasion. Having common histological features with other odontogenic ghost cell lesions (OGCL) like calcifying odontogenic cyst (COC) and dentinogenic ghost cell tumors, it is crucial to recognize GCOC malignant features, as it can be destructive and invasive, sometimes showing distant metastases and high recurrence rate. For this reason, it may entail more aggressive surgical approach and multimodal therapeutic regimen. Here we present a case report of GCOC arising in a previous COC, treated with surgical excision that showed persistence and recurrence after two years. The clinical and histological features of this rare occurrence are presented, in addition to the surgical approach, and a summary of literature review of OGCL.

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Titel: Ghost Cell Odontogenic Carcinoma Arising in a Previous Calcifying Odontogenic Cyst: A Case Report and Review of Literature
verfasst von: Ioana Ghita
Michael Y. Nagai
Joshua E. Lubek
Kristen M. Stashek
John R. Basile
Jeffery B. Price
John C. Papadimitriou
Donita Dyalram
Rania H. Younis
Publikationsdatum: 07.04.2022
Verlag: Springer US
Erschienen in: Head and Neck Pathology / Ausgabe 3/2022
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-022-01445-6

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

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Ghost Cell Odontogenic Carcinoma Arising in a Previous Calcifying Odontogenic Cyst: A Case Report and Review of Literature

Abstract

Neu im Fachgebiet Pathologie

Assistierter Suizid durch Infusion von Thiopental

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

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