Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Typ-2-Diabetes und Adipositas Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Häufige urologisch-sexualmedizinische Themen in der Praxis sind das Thema des MMW-Webinars am 5. Juni von 17.30 bis 19 Uhr. Konkret geht es um die Frage, wann bei Harnwegsinfektionen auf Antibiotika verzichtet werden kann, und um ein Update zur Therapie von Libido- und Potenzstörungen des Mannes. Der dritte Vortrag behandelt sexuell übertragbare Krankheiten. Stellen Sie Ihre Fragen an die Experten und sammeln Sie 2 CME-Punkte. Jetzt gleich anmelden!
Erweiterte Suche
Anmelden
nach oben
Current Pain and Headache Reports
Erschienen in: Current Pain and Headache Reports 1/2024

27.11.2023 | New and Emerging Therapies in Interventional Pain Medicine (J Hasoon, Section Editor)

Exploring Orthopedic Stem-Cell Approaches for Osteoarthritis Management: Current Trends and Future Horizons

verfasst von: Mark Ehioghae, Tarun K. Vippa, Dorothy Askins, Sonia Slusarczyk, Elena Bobo, Alexis Montoya, Danyon Anderson, Christopher L. Robinson, Alan D. Kaye, Ivan Urits

Erschienen in: Current Pain and Headache Reports | Ausgabe 1/2024

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

Osteoarthritis (OA) is a prevalent and debilitating condition characterized by joint degeneration and pain. Current treatment options aim to alleviate symptoms and slow disease progression but lack curative potential. Stem cell therapies have emerged as a promising alternative. This article explores the epidemiology, pathophysiology, clinical manifestations of hip and knee OA, and the evolving role of stem cell therapies in their treatment.

Recent Findings

The global prevalence of OA, with knee OA being the most common form, has fueled the demand for stem cell therapies. Despite limited robust evidence supporting their efficacy, clinical trials investigating stem-cell treatments for OA have reported encouraging radiological and clinical improvements. Stem cell therapies offer potential disease-modifying benefits through immunomodulatory actions, growth factor secretion, and chondrogenic capabilities. Adipose-derived mesenchymal stem cells (ADMSCs) have shown promise in clinical trials for OA treatment, offering potential pain relief and functional improvement. ADMSCs possess advantages such as accessibility and a favorable safety profile, making them a viable option for OA management. Although other stem-cell types, including human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs), have been used in OA treatment, ADMSCs have demonstrated superior outcomes.

Summary

By providing a comprehensive overview of the evolving landscape of stem cell therapies for hip and knee OA, this article highlights the potential of stem-cell treatments to address the limitations of current therapies. However, further research is required to establish their long-term efficacy, identify optimal stem-cell types, and develop standardized protocols.
Literatur
1.
2.
Wolfstadt JI, Cole BJ, Ogilvie-Harris DJ, Viswanathan S, Chahal J. Current Concepts. Sports health: a multidisciplinary approach. 2015;7(1):38–44.CrossRef
3.
Issa MR, Naja AS, Bouji NZ, Sagherian BH. The role of adipose-derived mesenchymal stem cells in knee osteoarthritis: a meta-analysis of randomized controlled trials. Ther Adv Musculoskelet Dis. 2022;14:1759720X2211460.
4.
Kraeutler MJ, Chahla J, LaPrade RF, Pascual-Garrido C. Biologic options for articular cartilage wear (platelet-rich plasma, stem cells, bone marrow aspirate concentrate). Clin Sports Med. 2017;36(3):457–68.PubMedCrossRef
5.
6.
Lu L, Dai C, Zhang Z, Du H, Li S, Ye P, et al. Treatment of knee osteoarthritis with intra-articular injection of autologous adipose-derived mesenchymal progenitor cells: a prospective, randomized, double-blind, active-controlled, phase IIb clinical trial. Stem Cell Res Ther. 2019;10(1):143.PubMedPubMedCentralCrossRef
7.
Hong Z, Chen J, Zhang S, Zhao C, Bi M, Chen X, et al. Intra-articular injection of autologous adipose-derived stromal vascular fractions for knee osteoarthritis: a double-blind randomized self-controlled trial. Int Orthop. 2019;43(5):1123–34.PubMedCrossRef
8.
Freitag J, Bates D, Wickham J, Shah K, Huguenin L, Tenen A, et al. Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: a randomized controlled trial. Regen Med. 2019;14(3):213–30.CrossRef
9.
Strotman PK, Novicoff WM, Nelson SJ, Browne JA. Increasing public interest in stem cell injections for osteoarthritis of the hip and knee: a google trends analysis. J Arthroplasty. 2019;34(6):1053–7.PubMedCrossRef
10.
Turner L, Knoepfler P. Selling stem cells in the USA: assessing the direct-to-consumer industry. Cell Stem Cell. 2016;19(2):154–7.PubMedCrossRef
11.
Evenbratt H, Andreasson L, Bicknell V, Brittberg M, Mobini R, Simonsson S. Insights into the present and future of cartilage regeneration and joint repair. Cell Regen. 2022;11(1):3.PubMedPubMedCentralCrossRef
12.
Tsvetkova AV, Vakhrushev IV, Basok YB, Grigor’Ev AM, Kirsanova LA, Lupatov AY, et al. Chondrogeneic potential of MSC from different sources in spheroid culture. Bull Exp Biol Med. 2021;170(4):528–36.
13.
Contentin R, Jammes M, Bourdon B, Cassé F, Bianchi A, Audigié F, et al. Bone marrow MSC secretome increases equine articular chondrocyte collagen accumulation and their migratory capacities. Int J Mol Sci. 2022;23(10):5795.PubMedPubMedCentralCrossRef
14.
• Lee E, Epanomeritakis IE, Lu V, Khan W. Bone marrow-derived mesenchymal stem cell implants for the treatment of focal chondral defects of the knee in animal models: a systematic review and meta-analysis. Int J Mol Sci. 2023;24(4):3227. Review of stem cell.PubMedPubMedCentralCrossRef
15.
16.
Marino-Martinez I, Martinez-Castro A, Pena-Martinez V, Acosta-Olivo C, Vilchez-Cavazos F, Guzman-Lopez A, et al. Human amniotic membrane intra-articular injection prevents cartilage damage in an osteoarthritis model. Exp Ther Med. 2018.
17.
Gomoll AH, Farr J, Cole BJ, Flanigan DC, Lattermann C, Mandelbaum BR, et al. Safety and efficacy of an amniotic suspension allograft injection over 12 months in a single-blinded, randomized controlled trial for symptomatic osteoarthritis of the knee. Arthros J Arthrosc Relat Surg. 2021;37(7):2246–57.
18.
Kunze KN, Burnett RA, Wright-Chisem J, Frank RM, Chahla J. Adipose-derived mesenchymal stem cell treatments and available formulations. Curr Rev Musculoskelet Med. 2020;13(3):264–80.PubMedPubMedCentralCrossRef
19.
Shariatzadeh M, Song J, Wilson SL. The efficacy of different sources of mesenchymal stem cells for the treatment of knee osteoarthritis. Cell Tissue Res. 2019;378(3):399–410.PubMedCrossRef
20.
21.
Mavrogenis AF, Karampikas V, Zikopoulos A, Sioutis S, Mastrokalos D, Koulalis D, et al. Orthobiologics: a review. Int Orthop. 2023.
22.
Cosenza S, Ruiz M, Toupet K, Jorgensen C, Noël D. Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis. Sci Rep. 2017;7(1):16214.PubMedPubMedCentralCrossRefADS
23.
Mamede AC, Carvalho MJ, Abrantes AM, Laranjo M, Maia CJ, Botelho MF. Amniotic membrane: from structure and functions to clinical applications. Cell Tissue Res. 2012;349(2):447–58.PubMedCrossRef
24.
McQuilling JP, Vines JB, Kimmerling KA, Mowry KC. Proteomic comparison of amnion and chorion and evaluation of the effects of processing on placental membranes. Wounds. 2017;29(6):E36-40.PubMedPubMedCentral
25.
26.
Gupta A, Maffulli N, Rodriguez HC, Lee CE, Levy HJ, El-Amin SF. Umbilical cord-derived Wharton’s jelly for treatment of knee osteoarthritis: study protocol for a non-randomized, open-label, multi-center trial. J Orthop Surg Res. 2021;16(1):143.PubMedPubMedCentralCrossRef
27.
Gupta A, El-Amin SF, Levy HJ, Sze-Tu R, Ibim SE, Maffulli N. Umbilical cord-derived Wharton’s jelly for regenerative medicine applications. J Orthop Surg Res. 2020;15(1):49.PubMedPubMedCentralCrossRef
28.
Gupta A, Maffulli N, Rodriguez HC, Mistovich RJ, Delfino K, Cady C, et al. Cell-free stem cell-derived extract formulation for treatment of knee osteoarthritis: study protocol for a preliminary non-randomized, open-label, multi-center feasibility and safety study. J Orthop Surg Res. 2021;16(1):514.PubMedPubMedCentralCrossRef
29.
Flannery CR, Seaman SA, Buddin KE, Nasert MA, Semler EJ, Kelley KL, et al. A novel placental tissue biologic, PTP-001, inhibits inflammatory and catabolic responses in vitro and prevents pain and cartilage degeneration in a rat model of osteoarthritis. Osteoarthr Cartil. 2021;29(8):1203–12.PubMedCrossRef
30.
Reece DS, Burnsed OA, Parchinski K, Marr EE, White RM, Salazar-Noratto GE, et al. Reduced size profile of amniotic membrane particles decreases osteoarthritis therapeutic efficacy. Tissue Eng Part A. 2020;26(1–2):28–37.PubMedCrossRef
31.
Kimmerling KA, Gomoll AH, Farr J, Mowry KC. Amniotic suspension allograft modulates inflammation in a rat pain model of osteoarthritis. J Orthop Res. 2020;38(5):1141–9.PubMedCrossRef
32.
Farr J, Gomoll AH, Yanke AB, Strauss EJ, Mowry KC. A randomized controlled single-blind study demonstrating superiority of amniotic suspension allograft injection over hyaluronic acid and saline control for modification of knee osteoarthritis symptoms. J Knee Surg. 2019;32(11):1143–54.PubMedCrossRef
33.
Topoluk N, Steckbeck K, Siatkowski S, Burnikel B, Tokish J, Mercuri J. Amniotic mesenchymal stem cells mitigate osteoarthritis progression in a synovial macrophage-mediated in vitro explant coculture model. J Tissue Eng Regen Med. 2018;12(4):1097–110.PubMedCrossRef
34.
Chen Y, Jiang W, Yong H, He M, Yang Y, Deng Z, et al. Macrophages in osteoarthritis: pathophysiology and therapeutics. Am J Transl Res. 2020;12(1):261–8.PubMedPubMedCentral
35.
Kwapisz A, Bowman M, Walters J, Cosh H, Burnikel B, Tokish J, et al. Human adipose- and amnion-derived mesenchymal stromal cells similarly mitigate osteoarthritis progression in the Dunkin Hartley guinea pig. Am J Sports Med. 2022;50(14):3963–73.PubMedCrossRef
36.
Kriston-Pál É, Haracska L, Cooper P, Kiss-Tóth E, Szukacsov V, Monostori É. A Regenerative approach to canine osteoarthritis using allogeneic, adipose-derived mesenchymal stem cells. Safety Results of a Long-Term Follow-Up. Front Vet Sci. 2020;7.
37.
Schiavone Panni A, Vasso M, Braile A, Toro G, De Cicco A, Viggiano D, et al. Preliminary results of autologous adipose-derived stem cells in early knee osteoarthritis: identification of a subpopulation with greater response. Int Orthop. 2019;43(1):7–13.PubMedCrossRef
38.
Sadri B, Tamimi A, Nouraein S, Bagheri Fard A, Mohammadi J, Mohammadpour M, et al. Clinical and laboratory findings following transplantation of allogeneic adipose-derived mesenchymal stromal cells in knee osteoarthritis, a brief report. Connect Tissue Res. 2022;63(6):663–74.PubMedCrossRef
39.
Yilmazer A, de Lázaro I, Bussy C, Kostarelos K. In vivo reprogramming of adult somatic cells to pluripotency by overexpression of Yamanaka factors. J Vis Exp. 2013;(82).
40.
Lach MS, Rosochowicz MA, Richter M, Jagiełło I, Suchorska WM, Trzeciak T. The induced pluripotent stem cells in articular cartilage regeneration and disease modelling: are we ready for their clinical use? Cells. 2022;11(3):529.PubMedPubMedCentralCrossRef
41.
Liu X, Li W, Fu X, Xu Y. The immunogenicity and immune tolerance of pluripotent stem cell derivatives. Front Immunol. 2017;2:8.ADS
42.
Deuse T, Hu X, Gravina A, Wang D, Tediashvili G, De C, et al. Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients. Nat Biotechnol. 2019;37(3):252–8.PubMedPubMedCentralCrossRef
43.
Miyazaki T, Hanamatsu H, Xu L, Onodera T, Furukawa JI, Homan K, et al. Evaluation of residual human-induced pluripotent stem cells in human chondrocytes by cell type-specific glycosphingolipid glycome analysis based on the aminolysis-SALSA technique. Int J Mol Sci. 2019;21(1):231.
44.
Yamashita A, Morioka M, Yahara Y, Okada M, Kobayashi T, Kuriyama S, et al. Generation of scaffoldless hyaline cartilaginous tissue from human iPSCs. Stem Cell Rep. 2015;4(3):404–18.PubMedPubMedCentralCrossRef
45.
46.
Venosa M, Calafiore F, Mazzoleni M, Romanini E, Cerciello S, Calvisi V. Platelet-rich plasma and adipose-derived mesenchymal stem cells in association with arthroscopic microfracture of knee articular cartilage defects: a pilot randomized controlled trial. Korovessis P, editor. Adv Orthop. 2022;2022:1–9.
47.
•• Tevlin R, DesJardins-Park H, Huber J, DiIorio SE, Longaker MT, Wan DC. Musculoskeletal tissue engineering: adipose derived stromal cell implementation for the treatment of osteoarthritis. Biomaterials. 2022;286: 121544. Adipose derived stem cells.PubMedPubMedCentralCrossRef
48.
•• Kim KI, Lee WS, Kim JH, Bae JK, Jin W. Safety and efficacy of the intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritic knee: a 5-year follow-up study. Stem Cells Transl Med. 2022;11(6):586–96. Stem cell longitudinal study.PubMedPubMedCentralCrossRef
49.
Hashimoto Y, Nishida Y, Takahashi S, Nakamura H, Mera H, Kashiwa K, et al. Transplantation of autologous bone marrow-derived mesenchymal stem cells under arthroscopic surgery with microfracture versus microfracture alone for articular cartilage lesions in the knee: a multicenter prospective randomized control clinical trial. Regen Ther. 2019;11:106–13.PubMedPubMedCentralCrossRef
50.
Koh YG, Kwon OR, Kim YS, Choi YJ, Tak DH. Adipose-derived mesenchymal stem cells with microfracture versus microfracture alone: 2-year follow-up of a prospective randomized trial. Arthrosc J Arthrosc Relat Surg. 2016;32(1):97–109.
51.
Dall’Oca C, Breda S, Elena N, Valentini R, Samaila EM, Magnan B. Mesenchymal stem cells injection in hip osteoarthritis: preliminary results. Acta Biomed. 2019;90(1-S):75–80.
52.
Burnham R, Smith A, Hart D. The safety and effectiveness of bone marrow concentrate injection for knee and hip osteoarthritis: a Canadian cohort. Regen Med. 2021;16(7):619–28.CrossRef
53.
Darrow M, Shaw B, Darrow B, Wisz S. Short-term outcomes of treatment of hip osteoarthritis with 4 bone marrow concentrate injections: a case series. Clin Med Insights Case Rep. 2018;10(11):117954761879157.CrossRef
54.
Tsubosaka M, Matsumoto T, Sobajima S, Matsushita T, Iwaguro H, Kuroda R. The influence of adipose-derived stromal vascular fraction cells on the treatment of knee osteoarthritis. BMC Musculoskelet Disord. 2020;21(1):207.PubMedPubMedCentralCrossRef
55.
Bright B, Bright R, Bright P, Limaye A. Ankylosing spondylitis, chronic fatigue and depression improved after stromal vascular fraction treatment for osteoarthritis: a case report. J Med Case Rep. 2018;12(1):238.PubMedPubMedCentralCrossRef
56.
Zeng L, Yu G, Yang K, Xiang W, Li J, Chen H. Efficacy and safety of mesenchymal stem cell transplantation in the treatment of autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, multiple sclerosis, and ankylosing spondylitis): a systematic review and. Mishra R, editor. Stem Cells Int. 2022;2022:1–20.
57.
Song JS, Hong KT, Kong CG, Kim NM, Jung JY, Park HS, et al. High tibial osteotomy with human umbilical cord blood-derived mesenchymal stem cells implantation for knee cartilage regeneration. World J Stem Cells. 2020;12(6):514–26.PubMedPubMedCentralCrossRef
58.
Gong J, Fairley J, Cicuttini FM, Hussain SM, Vashishtha R, Chou L, et al. Effect of stem cell injections on osteoarthritis-related structural outcomes: a systematic review. J Rheumatol. 2021;48(4):585–97.PubMedCrossRef
59.
Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 2011;7(1):33–42.PubMedCrossRef
60.
61.
Estes BT, Wu AW, Guilak F. Potent induction of chondrocytic differentiation of human adipose-derived adult stem cells by bone morphogenetic protein 6. Arthritis Rheum. 2006;54(4):1222–32.PubMedCrossRef
62.
63.
Leddy HA, Awad HA, Guilak F. Molecular diffusion in tissue-engineered cartilage constructs: Effects of scaffold material, time, and culture conditions. J Biomed Mater Res. 2004;70B(2):397–406.CrossRef
64.
Caplan AI, Dennis JE. Mesenchymal stem cells as trophic mediators. J Cell Biochem. 2006;98(5):1076–84.PubMedCrossRef
65.
Wu L, Leijten J, van Blitterswijk CA, Karperien M. Fibroblast growth factor-1 is a mesenchymal stromal cell-secreted factor stimulating proliferation of osteoarthritic chondrocytes in co-culture. Stem Cells Dev. 2013;22(17):2356–67.PubMedPubMedCentralCrossRef
66.
Peeters CMM, Leijs MJC, Reijman M, van Osch GJVM, Bos PK. Safety of intra-articular cell-therapy with culture-expanded stem cells in humans: a systematic literature review. Osteoarthr Cartil. 2013;21(10):1465–73.PubMedCrossRef
67.
Aneja A, Adams SB, Foster JA, Pezold R. AAOS technology overview summary: concentrated bone marrow aspirate for knee osteoarthritis. J Am Acad Orthop Surg. 2023;31(1):e9-13.PubMedCrossRef
68.
Chevalier X, Goupille P, Beaulieu AD, Burch FX, Bensen WG, Conrozier T, et al. Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum. 2009;61(3):344–52.PubMedCrossRef
69.
70.
Mehling B, Hric M, Salatkova A, Vetrak R, Santora D, Ovariova M, et al. A retrospective study of stromal vascular fraction cell therapy for osteoarthritis. J Clin Med Res. 2020;12(11):747–51.PubMedPubMedCentralCrossRef
Metadaten
Titel
Exploring Orthopedic Stem-Cell Approaches for Osteoarthritis Management: Current Trends and Future Horizons
verfasst von
Mark Ehioghae
Tarun K. Vippa
Dorothy Askins
Sonia Slusarczyk
Elena Bobo
Alexis Montoya
Danyon Anderson
Christopher L. Robinson
Alan D. Kaye
Ivan Urits
Publikationsdatum
27.11.2023
Verlag
Springer US
Erschienen in
Current Pain and Headache Reports / Ausgabe 1/2024
Print ISSN: 1531-3433
Elektronische ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-023-01191-6

Neu im Fachgebiet AINS

Mit dem Seitenschneider gegen das Reißverschluss-Malheur

03.06.2024 Urologische Notfallmedizin Nachrichten

Wer ihn je erlebt hat, wird ihn nicht vergessen: den Schmerz, den die beim Öffnen oder Schließen des Reißverschlusses am Hosenschlitz eingeklemmte Haut am Penis oder Skrotum verursacht. Eine neue Methode für rasche Abhilfe hat ein US-Team getestet.

Schlaganfall: Frühzeitige Blutdrucksenkung im Krankenwagen ohne Nutzen

31.05.2024 Apoplex Nachrichten

Der optimale Ansatz für die Blutdruckkontrolle bei Patientinnen und Patienten mit akutem Schlaganfall ist noch nicht gefunden. Ob sich eine frühzeitige Therapie der Hypertonie noch während des Transports in die Klinik lohnt, hat jetzt eine Studie aus China untersucht.

Reanimation bei Kindern – besser vor Ort oder während Transport?

29.05.2024 Reanimation im Kindesalter Nachrichten

Zwar scheint es laut einer Studie aus den USA und Kanada bei der Reanimation von Kindern außerhalb einer Klinik keinen Unterschied für das Überleben zu machen, ob die Wiederbelebungsmaßnahmen während des Transports in die Klinik stattfinden oder vor Ort ausgeführt werden. Jedoch gibt es dabei einige Einschränkungen und eine wichtige Ausnahme.

Nicht Creutzfeldt Jakob, sondern Abführtee-Vergiftung

29.05.2024 Hyponatriämie Nachrichten

Eine ältere Frau trinkt regelmäßig Sennesblättertee gegen ihre Verstopfung. Der scheint plötzlich gut zu wirken. Auf Durchfall und Erbrechen folgt allerdings eine Hyponatriämie. Nach deren Korrektur kommt es plötzlich zu progredienten Kognitions- und Verhaltensstörungen.

Update AINS

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

hier abonnieren
Bildnachweise