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Current HIV/AIDS Reports

19.10.2019 | Complications of HIV and Antiretroviral Therapy (GA McComsey, Section Editor)

Contemporary Issues in Pregnancy (and Offspring) in the Current HIV Era

verfasst von: Allison Ross Eckard, Stephanie E. Kirk, Nancy L. Hagood

Erschienen in: Current HIV/AIDS Reports

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Abstract

Purpose of Review

Although antiretroviral therapy (ART) has dramatically reduced mother to child transmission of HIV, data continue to mount that infants exposed to HIV in utero but are not infected (HEU) have serious negative health consequences compared to unexposed infants. This review evaluates recent literature on contemporary issues related to complications seen in pregnant women with HIV and their offspring.

Recent Findings

Current studies show that HEU infants are at a high risk of adverse outcomes, including premature birth, poor growth, neurodevelopmental impairment, immune dysfunction, infectious morbidity, and death. Etiologies for the observed clinical events and subclinical alterations are complex and multifactorial, and the long-term consequences of many findings are yet unknown.

Summary

HEU infants have an unacceptable rate of morbidity and mortality from perinatal HIV and ART exposure, even in the modern ART era. Continual monitoring and reporting is imperative to protect this vulnerable population in our everchanging landscape of HIV treatment and prevention.
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Metadaten
Titel
Contemporary Issues in Pregnancy (and Offspring) in the Current HIV Era
verfasst von
Allison Ross Eckard
Stephanie E. Kirk
Nancy L. Hagood
Publikationsdatum
19.10.2019
Verlag
Springer US
Erschienen in
Current HIV/AIDS Reports
Print ISSN: 1548-3568
Elektronische ISSN: 1548-3576
DOI
https://doi.org/10.1007/s11904-019-00465-2

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