Introduction
Methods
Subjects
Identification of AF cases
CMR protocol
Image analysis
- Maximum RA volume: RA volume at end-systole before tricuspid valve opening
- Minimum RA volume: RA volume at end-diastole before tricuspid valve closure
Covariates
Statistical analysis
Results
Developed AF N = 368 (11.7%) | No AF N = 2779 (88.3%) | P value | |
---|---|---|---|
Age (years), mean ± SD | 69.2 ± 8.0 | 61 ± 10 | < 0.001 |
Males, n(%) | 188 (51%) | 1231 (44%) | 0.01 |
Race, n(%) | < 0.001 | ||
Caucasian | 183 (50%) | 1032 (37%) | |
Hispanic | 57 (16%) | 603 (22%) | |
African American | 85 (23%) | 784 (28%) | |
Chinese | 43 (11%) | 361 (13%) | |
Smoker (past or current), n(%) | 204 (55%) | 1327 (48%) | 0.004 |
BMI (kg/m2), mean ± SD | 27.9 ± 5 | 27.9 ± 5.6 | 0.85 |
Systolic blood pressure (mmHg), mean ± SD | 133 ± 23 | 123 ± 20 | < 0.001 |
Diastolic blood pressure (mmHg), mean ± SD | 72 ± 10 | 72 ± 10 | 0.89 |
Taking blood pressure medication, n(%) | 180 (49%) | 880 (32%) | < 0.001 |
Total cholesterol (mg/dl), mean ± SD | 195 ± 35 | 195 ± 36 | 0.78 |
HDL (mg/dl), mean ± SD | 52.4 ± 16.2 | 51.4 ± 14.9 | 0.24 |
Taking lipid lowering medications, n(%) | 81 (22.1%) | 414 (14.9%) | < 0.001 |
Fasting glucose (mg/dL), mean ± SD | 102 ± 37 | 97 ± 31 | 0.009 |
Diabetes, n(%) | 0.054 | ||
Impaired fasting glucose | 50 (14%) | 343 (12%) | |
Diabetes | 64 (17%) | 365 (13%) | |
Alcohol Use | 0.34 | ||
Current | 198 (58%) | 1574 (57%) | |
Former | 94 (26%) | 615 (22%) |
RA structure and function
RA Parameter (mean ± SD) | Developed AF (n = 368) | No AF (n = 2779) | P-value |
---|---|---|---|
RA maximum volume indexed (mL/m2) | 23.7 ± 9.2 | 22.4 ± 8.0 | 0.002 |
RA minimum volume indexed (mL/m2) | 13.2 ± 6.7 | 12.1 ± 5.8 | < 0.001 |
RA total EF % | 44.8 ± 15.2 | 46.6 ± 15.1 | 0.02 |
RA global strain % | 34.0 ± 17.3 | 36.2 ± 19.2 | < 0.001 |
RA free-wall strain % | 39.9 ± 22.7 | 42.3 ± 25.9 | 0.049 |
Association of RA parameters and incident AF
RA Parameter | Unadjusted | Model 1 | Model 2 | |||
---|---|---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | |
RA maximum volume indexed | 1.16 (1.05,1.28) | 0.003 | 1.24 (1.12,1.36) | < 0.001 | 1.13 (1.00,1.27) | 0.041 |
RA minimum volume indexed | 1.18 (1.08,1.3) | 0.001 | 1.19 (1.08,1.31) | < 0.001 | 1.12 (1.01, 1.25) | 0.037 |
RA total EF % | 0.89 (0.8,0.99) | 0.03 | 0.95 (0.85,1.06) | 0.34 | 0.94 (0.83, 1.07) | 0.36 |
RA global strain % | 0.88 (0.79,0.98) | 0.02 | 1.06 (0.95,1.18) | 0.32 | 1.05 (0.92. 1.19) | 0.45 |
RA free-wall strain % | 0.9 (0.81,1.0) | 0.06 | 1.02 (0.92,1.14) | 0.63 | 1.01 (0.89, 1.15) | 0.82 |