Skip to main content
Erschienen in: Manuelle Medizin 1/2023

02.01.2023 | In der Diskussion

Achieving effective long-term therapeutic results in the treatment of chronic pain of musculoskeletal origin: the place of regenerative medicine

verfasst von: Dr. Osnat Wende

Erschienen in: Manuelle Medizin | Ausgabe 1/2023

Einloggen, um Zugang zu erhalten

Abstract

The use of regenerative medicine to treat injuries and degenerative conditions is gradually replacing more traditional methods. Regenerative techniques include prolotherapy, platelet-rich plasma, and stem cell injection, though the variety of injectable blood products is increasing. These techniques can be used to successfully treat conditions like partial tendon and ligament tears, chronic low back and neck pain, osteoarthritis, and even localized neuropathic disorders. In many instances, surgery may be avoided or at the very least delayed. Regenerative techniques will likely take the place of corticosteroid injections, which have been shown to only offer temporary relief for many of the musculoskeletal conditions treated, and frequently worsen the condition when repeated. Because the body develops various biomechanical compensatory mechanisms to avoid pain and function better, other body parts function suboptimally and eventually develop pathologies as well. Therefore, the practitioner must perform a methodical clinical evaluation to assess the musculoskeletal system as comprehensively as possible. Then one can best address the individual pathologies using the various tools at hand. Regenerative medicine has shown much potential in achieving successful long-term results, preventing much unnecessary surgery, and reducing the need for analgesia.
Literatur
1.
Zurück zum Zitat Sambandam SN, Khanna V, Gul A, Mounasamy V (2015) Rotator cuff tears: An evidence based approach. World J Orthop 6:902–918CrossRef Sambandam SN, Khanna V, Gul A, Mounasamy V (2015) Rotator cuff tears: An evidence based approach. World J Orthop 6:902–918CrossRef
2.
Zurück zum Zitat Kwong CA, Ono Y, Carroll MJ, Fruson LW, More KD, Thornton GM et al (2019) Full-thickness rotator cuff tears: what is the rate of tear progression? A systematic review. Arthroscopy 35:228–234CrossRef Kwong CA, Ono Y, Carroll MJ, Fruson LW, More KD, Thornton GM et al (2019) Full-thickness rotator cuff tears: what is the rate of tear progression? A systematic review. Arthroscopy 35:228–234CrossRef
3.
Zurück zum Zitat Ulucakoy C, Kaptan AY, Yapar A, Orhan O, Ozer M, Kanatli U (2021) The effect of bicipital groove morphology on the stability of the biceps long head tendon. Arch Orthop Trauma Surg 141:1325–1330CrossRef Ulucakoy C, Kaptan AY, Yapar A, Orhan O, Ozer M, Kanatli U (2021) The effect of bicipital groove morphology on the stability of the biceps long head tendon. Arch Orthop Trauma Surg 141:1325–1330CrossRef
5.
Zurück zum Zitat Young JJ, Hartvigsen J, Roos EM, Ammendolia C, Kongsted A, Skou ST et al (2021) Prevalence of lumbar spinal stenosis symptoms in patients from primary care treated for knee or hip osteoarthritis or low back pain. Osteoarthr Cartil 29:390–391CrossRef Young JJ, Hartvigsen J, Roos EM, Ammendolia C, Kongsted A, Skou ST et al (2021) Prevalence of lumbar spinal stenosis symptoms in patients from primary care treated for knee or hip osteoarthritis or low back pain. Osteoarthr Cartil 29:390–391CrossRef
6.
Zurück zum Zitat Young JJ, Jensen RK, Hartvigsen J, Roos EM, Ammendolia C, Juhl CB (2022) Prevalence of multimorbid degenerative lumbar spinal stenosis with knee or hip osteoarthritis: a systematic review and meta-analysis. BMC Musculoskelet Disord 23:177CrossRef Young JJ, Jensen RK, Hartvigsen J, Roos EM, Ammendolia C, Juhl CB (2022) Prevalence of multimorbid degenerative lumbar spinal stenosis with knee or hip osteoarthritis: a systematic review and meta-analysis. BMC Musculoskelet Disord 23:177CrossRef
8.
Zurück zum Zitat de Souza IMB, Sakaguchi TF, Yuan SLK, Matsutani LA, do de Espírito-Santo AS, de Pereira CAB et al (2019) Prevalence of low back pain in the elderly population: a systematic review. Clinics 74:e789CrossRef de Souza IMB, Sakaguchi TF, Yuan SLK, Matsutani LA, do de Espírito-Santo AS, de Pereira CAB et al (2019) Prevalence of low back pain in the elderly population: a systematic review. Clinics 74:e789CrossRef
9.
Zurück zum Zitat Bezuglov E, Lazarev A, Petrov A, Brodskaia A, Lyubushkina A, Kubacheva K et al (2021) Asymptomatic degenerative changes in the lumbar spine among professional soccer players. Spine 46:122–128CrossRef Bezuglov E, Lazarev A, Petrov A, Brodskaia A, Lyubushkina A, Kubacheva K et al (2021) Asymptomatic degenerative changes in the lumbar spine among professional soccer players. Spine 46:122–128CrossRef
10.
Zurück zum Zitat Thoreson O, Kovac P, Swärd A, Agnvall C, Todd C, Baranto A (2016) Back pain and MRI changes in the thoraco-lumbar spine of young elite Mogul skiers. Scand J Med Sci Sports. 27(9):983-989. Thoreson O, Kovac P, Swärd A, Agnvall C, Todd C, Baranto A (2016) Back pain and MRI changes in the thoraco-lumbar spine of young elite Mogul skiers. Scand J Med Sci Sports. 27(9):983-989.
11.
Zurück zum Zitat Kleinstück F, Dvorak J, Mannion AF (2006) Are “structural abnormalities” on magnetic resonance imaging a contraindication to the successful conservative treatment of chronic nonspecific low back pain? Spine 31(19):2250–2257CrossRef Kleinstück F, Dvorak J, Mannion AF (2006) Are “structural abnormalities” on magnetic resonance imaging a contraindication to the successful conservative treatment of chronic nonspecific low back pain? Spine 31(19):2250–2257CrossRef
12.
Zurück zum Zitat Ekedahl H, Jönsson B, Annertz M, Frobell RB (2018) Accuracy of clinical tests in detecting disk herniation and nerve root compression in subjects with lumbar radicular symptoms. Arch Phys Med Rehabil 99:726–735CrossRef Ekedahl H, Jönsson B, Annertz M, Frobell RB (2018) Accuracy of clinical tests in detecting disk herniation and nerve root compression in subjects with lumbar radicular symptoms. Arch Phys Med Rehabil 99:726–735CrossRef
13.
Zurück zum Zitat Pesonen J, Shacklock M, Suomalainen J‑S, Karttunen L, Mäki J, Airaksinen O et al (2021) Extending the straight leg raise test for improved clinical evaluation of sciatica: validity and diagnostic performance with reference to the magnetic resonance imaging. BMC Musculoskelet Disord 22:808CrossRef Pesonen J, Shacklock M, Suomalainen J‑S, Karttunen L, Mäki J, Airaksinen O et al (2021) Extending the straight leg raise test for improved clinical evaluation of sciatica: validity and diagnostic performance with reference to the magnetic resonance imaging. BMC Musculoskelet Disord 22:808CrossRef
14.
Zurück zum Zitat González Espinosa de los Monteros FJ, Gonzalez-Medina G, Ardila EMG, Mansilla JR, Expósito JP, Ruiz PO (2020) Use of neurodynamic or orthopedic tension tests for the diagnosis of lumbar and lumbosacral radiculopathies: study of the diagnostic validity. IJERPH 17:7046CrossRef González Espinosa de los Monteros FJ, Gonzalez-Medina G, Ardila EMG, Mansilla JR, Expósito JP, Ruiz PO (2020) Use of neurodynamic or orthopedic tension tests for the diagnosis of lumbar and lumbosacral radiculopathies: study of the diagnostic validity. IJERPH 17:7046CrossRef
15.
Zurück zum Zitat Jensen KT, Rabago DP, Best TM, Patterson JJ, Vanderby R (2008) Response of knee ligaments to prolotherapy in a rat injury model. Am J Sports Med 36:1347–1357CrossRef Jensen KT, Rabago DP, Best TM, Patterson JJ, Vanderby R (2008) Response of knee ligaments to prolotherapy in a rat injury model. Am J Sports Med 36:1347–1357CrossRef
16.
Zurück zum Zitat Nair LS (2011) Prolotherapy for tissue repair. Transl Res 158:129–131CrossRef Nair LS (2011) Prolotherapy for tissue repair. Transl Res 158:129–131CrossRef
17.
Zurück zum Zitat Freeman JW, Empson YM, Ekwueme EC, Paynter DM, Brolinson PG (2011) Effect of prolotherapy on cellular proliferation and collagen deposition in MC3T3-E1 and patellar tendon fibroblast populations. Transl Res 158:132–139CrossRef Freeman JW, Empson YM, Ekwueme EC, Paynter DM, Brolinson PG (2011) Effect of prolotherapy on cellular proliferation and collagen deposition in MC3T3-E1 and patellar tendon fibroblast populations. Transl Res 158:132–139CrossRef
18.
Zurück zum Zitat Chang S‑F, Huang K‑C, Cheng C‑C, Su Y‑P, Lee K‑C, Chen C‑N et al (2017) Glucose adsorption to chitosan membranes increases proliferation of human chondrocyte via mammalian target of rapamycin complex 1 and sterol regulatory element-binding protein‑1 signaling. J Cell Physiol 232:2741–2749CrossRef Chang S‑F, Huang K‑C, Cheng C‑C, Su Y‑P, Lee K‑C, Chen C‑N et al (2017) Glucose adsorption to chitosan membranes increases proliferation of human chondrocyte via mammalian target of rapamycin complex 1 and sterol regulatory element-binding protein‑1 signaling. J Cell Physiol 232:2741–2749CrossRef
19.
Zurück zum Zitat Johnston E, Kou Y, Junge J, Chen L, Kochan A, Johnston M et al (2021) Hypertonic dextrose stimulates chondrogenic cells to deposit collagen and proliferate. Cartilage 13:213S–224SCrossRef Johnston E, Kou Y, Junge J, Chen L, Kochan A, Johnston M et al (2021) Hypertonic dextrose stimulates chondrogenic cells to deposit collagen and proliferate. Cartilage 13:213S–224SCrossRef
20.
Zurück zum Zitat Sert AT, Sen EI, Esmaeilzadeh S, Ozcan E (2020) The effects of dextrose prolotherapy in symptomatic knee osteoarthritis: a randomized controlled study. J Altern Complement Med 26:409–417CrossRef Sert AT, Sen EI, Esmaeilzadeh S, Ozcan E (2020) The effects of dextrose prolotherapy in symptomatic knee osteoarthritis: a randomized controlled study. J Altern Complement Med 26:409–417CrossRef
21.
Zurück zum Zitat Rezasoltani Z, Taheri M, Mofrad MK, Mohajerani SA (2017) Periarticular dextrose prolotherapy instead of intra-articular injection for pain and functional improvement in knee osteoarthritis. J Pain Res 10:1179–1187CrossRef Rezasoltani Z, Taheri M, Mofrad MK, Mohajerani SA (2017) Periarticular dextrose prolotherapy instead of intra-articular injection for pain and functional improvement in knee osteoarthritis. J Pain Res 10:1179–1187CrossRef
22.
Zurück zum Zitat Krstičević M, Jerić M, Došenović S, Jeličić Kadić A, Puljak L (2017) Proliferative injection therapy for osteoarthritis: a systematic review. Int Orthop 41:671–679CrossRef Krstičević M, Jerić M, Došenović S, Jeličić Kadić A, Puljak L (2017) Proliferative injection therapy for osteoarthritis: a systematic review. Int Orthop 41:671–679CrossRef
23.
Zurück zum Zitat Topol GA, Podesta LA, Reeves KD, Giraldo MM, Johnson LL, Grasso R et al (2016) Chondrogenic effect of intra-articular hypertonic-dextrose (Prolotherapy) in severe knee osteoarthritis. PM R 8:1072–1082CrossRef Topol GA, Podesta LA, Reeves KD, Giraldo MM, Johnson LL, Grasso R et al (2016) Chondrogenic effect of intra-articular hypertonic-dextrose (Prolotherapy) in severe knee osteoarthritis. PM R 8:1072–1082CrossRef
25.
Zurück zum Zitat Li Z, Weng X (2022) Platelet-rich plasma use in meniscus repair treatment: a systematic review and meta-analysis of clinical studies. J Orthop Surg Res 17:446CrossRef Li Z, Weng X (2022) Platelet-rich plasma use in meniscus repair treatment: a systematic review and meta-analysis of clinical studies. J Orthop Surg Res 17:446CrossRef
26.
Zurück zum Zitat Sanapati J, Manchikanti L, Atluri S, Jordan S, Albers SL, Pappolla MA et al (2018) Do regenerative medicine therapies provide long-term relief in chronic low back pain: a systematic review and metaanalysis. Pain Physician 21:515–540 Sanapati J, Manchikanti L, Atluri S, Jordan S, Albers SL, Pappolla MA et al (2018) Do regenerative medicine therapies provide long-term relief in chronic low back pain: a systematic review and metaanalysis. Pain Physician 21:515–540
27.
Zurück zum Zitat Xuan Z, Yu W, Dou Y, Wang T (2020) Efficacy of platelet-rich plasma for low back pain: a systematic review and meta-analysis. J Neurol Surg A Cent Eur Neurosurg 81:529–534CrossRef Xuan Z, Yu W, Dou Y, Wang T (2020) Efficacy of platelet-rich plasma for low back pain: a systematic review and meta-analysis. J Neurol Surg A Cent Eur Neurosurg 81:529–534CrossRef
28.
Zurück zum Zitat Sari A, Eroglu A (2020) Comparison of ultrasound-guided platelet-rich plasma, prolotherapy, and corticosteroid injections in rotator cuff lesions. J Back Musculoskelet Rehabil 33:387–396CrossRef Sari A, Eroglu A (2020) Comparison of ultrasound-guided platelet-rich plasma, prolotherapy, and corticosteroid injections in rotator cuff lesions. J Back Musculoskelet Rehabil 33:387–396CrossRef
29.
Zurück zum Zitat Rothenberg JB, Godha K, Civitarese DM, Malanga G, Singh JR, Panero A et al (2021) Pain and functional outcomes of the sacroiliac joint after platelet-rich plasma injection: a descriptive review. Regen Med 16:87–100CrossRef Rothenberg JB, Godha K, Civitarese DM, Malanga G, Singh JR, Panero A et al (2021) Pain and functional outcomes of the sacroiliac joint after platelet-rich plasma injection: a descriptive review. Regen Med 16:87–100CrossRef
30.
Zurück zum Zitat Zhou W, Lin J, Zhao K, Jin K, He Q, Hu Y et al (2019) Single-cell profiles and clinically useful properties of human mesenchymal stem cells of adipose and bone marrow origin. Am J Sports Med 47:1722–1733CrossRef Zhou W, Lin J, Zhao K, Jin K, He Q, Hu Y et al (2019) Single-cell profiles and clinically useful properties of human mesenchymal stem cells of adipose and bone marrow origin. Am J Sports Med 47:1722–1733CrossRef
31.
Zurück zum Zitat Everts P, Onishi K, Jayaram P, Lana JF, Mautner K (2020) Platelet-rich plasma: new performance understandings and therapeutic considerations in 2020. IJMS 21:7794CrossRef Everts P, Onishi K, Jayaram P, Lana JF, Mautner K (2020) Platelet-rich plasma: new performance understandings and therapeutic considerations in 2020. IJMS 21:7794CrossRef
32.
Zurück zum Zitat Zhao J, Huang H, Liang G, Zeng L, Yang W, Liu J (2020) Effects and safety of the combination of platelet-rich plasma (PRP) and hyaluronic acid (HA) in the treatment of knee osteoarthritis: a systematic review and meta-analysis. BMC Musculoskelet Disord 21:224CrossRef Zhao J, Huang H, Liang G, Zeng L, Yang W, Liu J (2020) Effects and safety of the combination of platelet-rich plasma (PRP) and hyaluronic acid (HA) in the treatment of knee osteoarthritis: a systematic review and meta-analysis. BMC Musculoskelet Disord 21:224CrossRef
33.
Zurück zum Zitat Aw AAL, Leeu JJ, Tao X, Bin Abd Razak HR (2021) Comparing the efficacy of dual Platelet-Rich Plasma (PRP) and Hyaluronic Acid (HA) therapy with PRP-alone therapy in the treatment of knee osteoarthritis: a systematic review and meta-analysis. J Exp Orthop 8:101CrossRef Aw AAL, Leeu JJ, Tao X, Bin Abd Razak HR (2021) Comparing the efficacy of dual Platelet-Rich Plasma (PRP) and Hyaluronic Acid (HA) therapy with PRP-alone therapy in the treatment of knee osteoarthritis: a systematic review and meta-analysis. J Exp Orthop 8:101CrossRef
34.
Zurück zum Zitat Ip HL, Nath DK, Sawleh SH, Kabir MH, Jahan N (2020) Regenerative medicine for knee osteoarthritis—the efficacy and safety of intra-articular platelet-rich plasma and mesenchymal stem cells injections: a literature review. Cureus 12:e10575 Ip HL, Nath DK, Sawleh SH, Kabir MH, Jahan N (2020) Regenerative medicine for knee osteoarthritis—the efficacy and safety of intra-articular platelet-rich plasma and mesenchymal stem cells injections: a literature review. Cureus 12:e10575
Metadaten
Titel
Achieving effective long-term therapeutic results in the treatment of chronic pain of musculoskeletal origin: the place of regenerative medicine
verfasst von
Dr. Osnat Wende
Publikationsdatum
02.01.2023
Verlag
Springer Medizin
Erschienen in
Manuelle Medizin / Ausgabe 1/2023
Print ISSN: 0025-2514
Elektronische ISSN: 1433-0466
DOI
https://doi.org/10.1007/s00337-022-00934-7

Weitere Artikel der Ausgabe 1/2023

Manuelle Medizin 1/2023 Zur Ausgabe

MM aktuell

MM aktuell

Informationen der DGOM

Informationen der DGOM

Informationen aus Österreich

Informationen aus Österreich

Informationen der DAAO

Informationen der DAAO

Informationen aus Österreich

Informationen aus Österreich

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Knie-TEP: Kein Vorteil durch antibiotikahaltigen Knochenzement

29.05.2024 Periprothetische Infektionen Nachrichten

Zur Zementierung einer Knie-TEP wird in Deutschland zu über 98% Knochenzement verwendet, der mit einem Antibiotikum beladen ist. Ob er wirklich besser ist als Zement ohne Antibiotikum, kann laut Registerdaten bezweifelt werden.

Häusliche Gewalt in der orthopädischen Notaufnahme oft nicht erkannt

28.05.2024 Häusliche Gewalt Nachrichten

In der Notaufnahme wird die Chance, Opfer von häuslicher Gewalt zu identifizieren, von Orthopäden und Orthopädinnen offenbar zu wenig genutzt. Darauf deuten die Ergebnisse einer Fragebogenstudie an der Sahlgrenska-Universität in Schweden hin.

Fehlerkultur in der Medizin – Offenheit zählt!

28.05.2024 Fehlerkultur Podcast

Darüber reden und aus Fehlern lernen, sollte das Motto in der Medizin lauten. Und zwar nicht nur im Sinne der Patientensicherheit. Eine negative Fehlerkultur kann auch die Behandelnden ernsthaft krank machen, warnt Prof. Dr. Reinhard Strametz. Ein Plädoyer und ein Leitfaden für den offenen Umgang mit kritischen Ereignissen in Medizin und Pflege.

Mehr Frauen im OP – weniger postoperative Komplikationen

21.05.2024 Allgemeine Chirurgie Nachrichten

Ein Frauenanteil von mindestens einem Drittel im ärztlichen Op.-Team war in einer großen retrospektiven Studie aus Kanada mit einer signifikanten Reduktion der postoperativen Morbidität assoziiert.

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.